CD40 Protein (CD40) (partial) (His tag)

N° du produit ABIN5608422

Cette protéine Recombinant CD40 est produite dans HEK-293 Cells.

Aperçu rapide pour CD40 Protein (CD40) (partial) (His tag) (ABIN5608422)

Antigène: CD40

Type de proteíne: Recombinant

Origine: Macaque rhésus

Source: HEK-293 Cells

Application: Western Blotting (WB)

Pureté: >95 % as determined by SDS-PAGE.

Détail du produit

Attributs du protein: partial

Purification/Conjugué: Cette CD40 protéine est marqué à la His tag.

Séquence: Glu 21 - Arg 193

niveau d'endotoxine: Endotoxin level is less than 1.0 EU per ug by the LAL method.

Information d'application

Indications d'application: This recombinant protein can be used for WB.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: PBS, pH 7.4

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C,-80 °C

Stockage commentaire: Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C.

Détail du antigène

Antigène: CD40

Autre désignation: CD40

Sujet: CD40 is also known as TNFRSF5, Bp50, CDW40, MGC9013, TNFRSF5 and p50, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins, and plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects. CD40 contains 4 cysteine-rich repeats in the extracellular domain, and is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. The extracellular domain has the cysteinerich repeat regions, which are characteristic for many of the receptors of the TNF superfamily. Interaction of CD40 with its ligand, CD40L, leads to aggregation of CD40 Molecules,which in turn interact with cytoplasmic components to initiate signaling pathways. Early studies on the CD40-CD40L system revealed its role in humoral immunity. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3), an autosomal recessive disorder characterized by an inability of B cells to undergo isotype switching, as well as an inability to mount an antibody-specific immune response, and a lack of germinal center formation.

Poids moléculaire: 21.1 kDa

ID gène: 707749

NCBI Accession: NP_001252791

Pathways: Signalisation NF-kappaB, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints