C5A Protein (AA 678-751)

N° du produit ABIN6809880

Cette protéine Recombinant C5A est exprimée dans Escherichia coli (E. coli).

Aperçu rapide pour C5A Protein (AA 678-751) (ABIN6809880)

Antigène: C5A (C5a) (Complement Component 5a (C5a))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Cynomolgus

Source: Escherichia coli (E. coli)

Pureté: >95 % as determined by SDS-PAGE.

Détail du produit

Attributs du protein: AA 678-751

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: PBS, pH 7.4

Stock: -20 °C

Détail du antigène

Antigène: C5A (C5a) (Complement Component 5a (C5a))

Autre désignation: Complement Component C5a

Sujet: Complement Component C5a (C5a) is also known as C5,and is a protein fragment released from complement component C5.,is a potent chemotactic factor for human peripheral blood neutrophils and monocytes, and is believed to play an important role in a number of inflammatory conditions. There are several functions in the below: C5a is an anaphylatoxin, causing the release of histamine from mast cells, C5a is effective leukocyte chemoattractants, causing the accumulation of white blood cells, especially neutrophil granulocytes, at sites of complement activation, C5a activates white blood cells by increasing avidity for white blood cell integrins and upregulating the Lipoxygenase pathway for arachidonic acid metabolism, C5a is a powerful inflammatory mediator, and seems to be a key factor in the development of pathology of many inflammatory diseases involving the complement system, C5a modulates balance between activating versus inhibitory IgG Fc receptors on leukocytes, thereby enhancing autoimmune response.

Poids moléculaire: 8.4 kDa

NCBI Accession: XP_015292262

Pathways: Système du Complément, Carbohydrate Homeostasis