Ret Proto-Oncogene Protein (RET) (Fc Tag)
Aperçu rapide pour Ret Proto-Oncogene Protein (RET) (Fc Tag) (ABIN6964355)
Antigène
Voir toutes Ret Proto-Oncogene (RET) ProtéinesType de proteíne
Origine
Source
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Purification/Conjugué
- Cette Ret Proto-Oncogene protéine est marqué à la Fc Tag.
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Séquence
- RET (Leu29-Arg635)+hFc(GLU99-ALA330)
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Attributs du produit
- Tagged Protein: C-Human Fc tag
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Purification
- affinity purification
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Ret Proto-Oncogene (RET) (AA 25-458) protein (GST tag)
RET Origine: Humain Hôte: Wheat germ Recombinant WB, ELISA, AP, AA
Ret Proto-Oncogene (RET) (AA 29-635) protein (His tag)RET Origine: Humain Hôte: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
Ret Proto-Oncogene (RET) protein (DYKDDDDK Tag)RET Origine: Humain Hôte: Insect cells (Sf9) Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Ret Proto-Oncogene (RET) protein (DYKDDDDK-His Tag)RET Origine: Humain Hôte: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Indications d'application
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Reconstitute with deionized water
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Buffer
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
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Agent conservateur
- Without preservative
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Stock
- -80 °C
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Stockage commentaire
- Store at -80°C for 12 months (Avoid repeated freezing and thawing)
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Date de péremption
- 12 months
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- Ret Proto-Oncogene (RET)
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Autre désignation
- RET
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Sujet
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Synonymes: CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET-ELE1
Description: This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differentiation, growth, migration and survival. The encoded receptor is important in development of the nervous system, and the development of organs and tissues derived from the neural crest. This proto-oncogene can undergo oncogenic activation through both cytogenetic rearrangement and activating point mutations. Mutations in this gene are associated with Hirschsprung disease and central hypoventilation syndrome and have been identified in patients with renal agenesis. [provided by RefSeq, Sep 2017] -
Poids moléculaire
- 92.29 kDa
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UniProt
- P07949
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Pathways
- Signalisation RTK, Dopaminergic Neurogenesis, Regulation of Cell Size, Tube Formation
Antigène
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