IL-13 Protein (His tag)

N° du produit ABIN7121398

Protéine Recombinant IL-13 exprimée dans HEK-293 Cells.

Aperçu rapide pour IL-13 Protein (His tag) (ABIN7121398)

Antigène: IL-13 (IL13) (Interleukin 13 (IL13))

Type de proteíne: Recombinant

Origine: Chien

Source: HEK-293 Cells

Pureté: >90 % as determined by SDS-PAGE.

Détail du produit

Purification/Conjugué: Cette IL-13 protéine est marqué à la His tag.

Fonction: Canine IL-13 Protein, His Tag

Séquence: Ser 19 - Arg 131

Attributs du produit: Canine IL-13, His Tag (IL3-C52H4) is expressed from human 293 cells (HEK293). It contains AA Ser 19 - Arg 131 (Accession # NP_001003384.1).

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Information d'application

Indications d'application: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 14.3 kDa. The protein migrates as 30-35 kDa under reducing (R) condition due to glycosylation.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: PBS, pH 7.4

Stock: -20 °C

Stockage commentaire: -20°C

Détail du antigène

Antigène: IL-13 (IL13) (Interleukin 13 (IL13))

Autre désignation: IL-13

Sujet: Synonyms: IL13,ALRH,BHR1,MGC116786,MGC116788,MGC116789,P600,Interleukin-13,
Description: Interleukin 13 (IL13) is also known as ALRH, BHR1and P600, is a single-chain glycosylated polypeptide, and is a cytokine critical in regulating inflammatory and immune responses. IL13 is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL-13 induces its effects through a multi-subunit receptor that includes the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains. The functions of IL-13 overlap considerably with those of IL-4, especially with regard to changes induced on hematopoietic cells, but these effects are probably less important given the more potent role of IL-4. IL-13 induces matrix metalloproteinases (MMPs) as part of a mechanism that protects against excessive allergic inflammation that predisposes to asphyxiation. IL-13 induces many features of allergic lung disease, including airway hyperresponsiveness, goblet cell metaplasia and mucus hypersecretion, which all contribute to airway obstruction.

Poids moléculaire: 14.3 kDa

NCBI Accession: NP_001003384

Pathways: Signalistation JAK/STAT, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Proton Transport