IL-15 Protein (His tag)

N° du produit ABIN7121480

Cette protéine Recombinant IL-15 est produite dans HEK-293 Cells.

Aperçu rapide pour IL-15 Protein (His tag) (ABIN7121480)

Antigène: IL-15 (IL15) (Interleukin 15 (IL15))

Type de proteíne: Recombinant

Origine: Macaque rhésus, Cynomolgus

Source: HEK-293 Cells

Pureté: >95 % as determined by SDS-PAGE.

Détail du produit

Purification/Conjugué: Cette IL-15 protéine est marqué à la His tag.

Fonction: Cynomolgus / Rhesus macaque IL-15 Protein, His Tag

Séquence: Asn 49 - Ser 162

Attributs du produit: Cynomolgus / Rhesus macaque IL-15, His Tag (IL5-C52H4) is expressed from human 293 cells (HEK293). It contains AA Asn 49 - Ser 162 (Accession # P48092-1).

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Information d'application

Indications d'application: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 14.9 kDa. The protein migrates as 14 kDa and 16-18 kDa under reducing (R) condition due to glycosylation.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: PBS, pH 7.4

Stock: -20 °C

Stockage commentaire: -20°C

Détail du antigène

Antigène: IL-15 (IL15) (Interleukin 15 (IL15))

Autre désignation: IL-15

Sujet: Synonyms: IL-15,Interleukin-15,MGC9721,
Description: Interleukin 15 is also known as IL15, IL-15, and is a cytokine with structural similarity to IL-2. Like IL-2, IL-15 binds to and signals through the IL-2/IL-15 beta chain (CD122) and the common gamma chain (gamma-C, CD132). IL-15 is secreted by mononuclear phagocytes (and some other cells) following infection by virus(es). This cytokine induces cell proliferation of natural killer cells, cells of the innate immune system whose principal role is to kill virally infected cells. Interleukin 15 (IL-15) regulates T and natural killer (NK) cell activation and proliferation. Survival signals that maintain memory T cells in the absence of antigen are provided by IL-15. This cytokine is also implicated in NK cell development. In rodent lymphocytes, IL-15 prevents apoptosis by inducing an apoptosis inhibitor, BCL2L1/BCL-x(L). IL-15 has been shown to enhance the anti-tumor immunity of CD8+ T cells in pre-clinical models. A phase I clinical trial to evaluate the safety, dosing, and anti-tumor efficacy of IL-15 in patients with metastatic melanoma and renal cell carcinoma (kidney cancer) has begun to enroll patients at the National Institutes of Health.

Poids moléculaire: 14.9 kDa

NCBI Accession: NP_001038196

Pathways: Signalistation JAK/STAT, Glycosaminoglycan Metabolic Process