Adenylosuccinate Lyase Protein (ADSL) (His tag)

N° du produit ABIN7317594

Cette protéine Recombinant Adenylosuccinate Lyase est produite dans Escherichia coli (E. coli).

Aperçu rapide pour Adenylosuccinate Lyase Protein (ADSL) (His tag) (ABIN7317594)

Antigène: Adenylosuccinate Lyase (ADSL)

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Pureté: > 95 % as determined by reducing SDS-PAGE.

Détail du produit

Purification/Conjugué: Cette Adenylosuccinate Lyase protéine est marqué à la His tag.

Fonction: Recombinant Human ADSL/Adenylosuccinate Lyase Protein (His Tag)

Séquence: Met 1-Leu 484

Attributs du produit: A DNA sequence encoding the human ADSL (P30566-1) (Met 1-Leu 484) was expressed, with a polyhistidine tag at the N-terminus.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, 10 % glycerol, pH 7.5

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: Adenylosuccinate Lyase (ADSL)

Autre désignation: ADSL/Adenylosuccinate Lyase

Sujet:

Background: Adenylosuccinate lyase, also known as adenylosuccinase, ADSL or ASL, is an enzyme implicated in the reaction of adenylosuccinat converting to AMP and fumarate as part of the purine nucleotide cycle. The two substates of adenylosuccinate lyase (ADSL) are dephosphorylated derivatives of SAICA ribotide (SAICAR) and adenylosuccinate (S-AMP), which catalyzes an important reaction in the de novo pathway of purine biosynthesis. ADSL catalyzes two distinct reactions in the synthesis of purine nucleotides, both of which involve the _-elimination of fumarate to produce either aminoimidazole carboxamide ribotide from SAICAR or AMP from S-AMP. The Adenylosuccinate lyase deficiency is a rare autosomal recessive metabolic disorder characterized by the present of SAICA riboside and succinyladenosine (S-Ado). ADSL defect in different patients is often caused by different mutations to the enzyme.

Synonym: AMPS,ASASE,ASL

Poids moléculaire: 57 kDa

Pathways: Ribonucleoside Biosynthetic Process