Adrenomedullin Protein (ADM) (Fc Tag)

N° du produit ABIN7317512

Cette protéine Recombinant Adrenomedullin est produite dans HEK-293 Cells.

Aperçu rapide pour Adrenomedullin Protein (ADM) (Fc Tag) (ABIN7317512)

Antigène: Adrenomedullin (ADM)

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Pureté: > 93 % as determined by reducing SDS-PAGE.

Détail du produit

Purification/Conjugué: Cette Adrenomedullin protéine est marqué à la Fc Tag.

Fonction: Recombinant Human ADM/Adrenomedullin Protein (Fc Tag)

Séquence: Tyr95-Tyr146

Attributs du produit: A DNA sequence encoding the human ADM (P35318) (Tyr95-Tyr146) was expressed, with the fused Fc region of human IgG1 at the N-terminus.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: Adrenomedullin (ADM)

Autre désignation: ADM/Adrenomedullin

Classe de substances: Hormone

Sujet:

Background: Adrenomedullin consists of 52 amino acids and is a member of the adrenomedullin family. It s a a hypotensive peptide and has 1 intramolecular disulfide bond. It seems that adrenomedullin has a slight homology with the calcitonin gene-related peptide. Adrenomedullin has a highly expression in pheochromocytoma and adrenal medulla. It also can be detected in lung, ventricle and kidney tissues. Adrenomedullin and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, adrenomedullin is diuretic and natriuretic, and both adrenomedullin and PAMP inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels. It is believed that adrenomedullin functions through combinations of the calcitonin receptor like receptor and receptor activity-modifying proteins complexes, as well as CGRP receptors.

Synonym: AM,PAMP

Poids moléculaire: 38 kDa

UniProt: P35318

Pathways: Hormone Transport, Hormone Activity, C21-Steroid Hormone Metabolic Process, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Tube Formation