CD147 Protéine

N° du produit ABIN7317976

Cette protéine Recombinant CD147 est exprimée dans HEK-293 Cells.

Aperçu rapide pour CD147 Protéine (ABIN7317976)

Antigène: CD147 (BSG) (Basigin (Ok Blood Group) (BSG))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Pureté: > 97 % as determined by reducing SDS-PAGE.

Détail du produit

Fonction: Recombinant Human CD147/Basigin Protein

Séquence: Met 1-His 205

Attributs du produit: The mature form of human CD147 (NP_940991.1) extracellular domain (Met 1-His 205) with quinary-aa peptide (DDDDK) at the C-terminus was expressed and purified.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 50 mM Tris, 100 mM NaCl, pH 8.0

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: CD147 (BSG) (Basigin (Ok Blood Group) (BSG))

Autre désignation: CD147/Basigin

Sujet:

Background: CD147/EMMPRIN (Extracellular Matrix Metalloproteinase Inducer), also known as Basigin (BSG), is a transmembrane glycoprotein with different forms resulted from different modes of glycosylation and N-terminal sequence variants. It is a member of the immunoglobulin superfamily with homology to both the immunoglobulin V domain and MHC class II antigen beta-chain. This protein play important roles in variety of events including spermatogenesis, embryo implantation, neural network formation. CD147 induces the production and release of matrix metalloproteinases (MMP) in the surrounding mesenchymal cells and tumor cells, and thereby promotes invasion, metastasis, growth and survival of malignant cells. Furthermore, CD147 also serves as a receptor for extracellular cyclophilinthe and its association with integrins might be important in signal transduction. Recently, CD147 displays increased expression in many cancers, and it has been previously demonstrated to participate in cancer metastasis and progression. Thus, CD147 and its antibody are used as an effective treatment for malignant cancers.

Synonym: Basigin, 5F7, Collagenase Stimulatory Factor, Extracellular Matrix Metalloproteinase Inducer, EMMPRIN, Leukocyte Activation Antigen M6, OK Blood Group Antigen, Tumor Cell-Derived Collagenase Stimulatory Factor, TCSF, CD147, BSG

Poids moléculaire: 20.7 kDa

NCBI Accession: NP_940991

Pathways: S100 Proteins