MERTK Protein (AA 573-867) (His-GST)

N° du produit ABIN7320009

Protéine Recombinant MERTK exprimée dans Baculovirus infected Insect Cells.

Aperçu rapide pour MERTK Protein (AA 573-867) (His-GST) (ABIN7320009)

Antigène: MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Souris

Source: Baculovirus infected Insect Cells

Pureté: > 96 % as determined by reducing SDS-PAGE.

Détail du produit

Attributs du protein: AA 573-867

Purification/Conjugué: Cette MERTK protéine est marqué à la His-GST.

Fonction: Recombinant Mouse MERTK/MER Protein (His & GST Tag)

Séquence: Glu573-Tyr867

Attributs du produit: A DNA sequence encoding the mouse MERTK (Q60805) (Glu573-Tyr867) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: The specific activity was determined to be 30 nmol/min/mg using Poly(Glu, Tyr) 4:1 as substrate.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Supplied as sterile solution of 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Date de péremption: 6 months

Détail du antigène

Antigène: MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))

Autre désignation: MERTK/MER

Sujet: Eyk,Mer,Nyk,nmf12,Proto-oncogene tyrosine-protein kinase MER (MERTK) is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. MERTK is localized in membrane and is no expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines. This protein is highly expressed in testis, ovary, prostate, lung, and kidney, with lower expression in spleen, small intestine, colon, and liver. MERTK regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. MERTK plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. Defects in MERTK are the cause of retinitis pigmentosa type 38.

Poids moléculaire:

Calculated MW: 61.7 kDa

Observed MW: 58 kDa

UniProt: Q60805

Pathways: Signalisation RTK