CPE Protein (His tag)

N° du produit ABIN7318246

Cette protéine Recombinant CPE est exprimée dans Human Cells.

Aperçu rapide pour CPE Protein (His tag) (ABIN7318246)

Antigène: CPE (Carboxypeptidase E (CPE))

Type de proteíne: Recombinant

Origine: Humain

Source: Human Cells

Pureté: > 95 % as determined by reducing SDS-PAGE.

Détail du produit

Purification/Conjugué: Cette CPE protéine est marqué à la His tag.

Fonction: Recombinant Human Carboxypeptidase E/CPE Protein (His Tag)

Séquence: Arg42-Ser453

Attributs du produit: Recombinant Human Carboxypeptidase E is produced by our Mammalian expression system and the target gene encoding Arg42-Ser453 is expressed with a 6His tag at the C-terminus.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM TrisHCl,150 mM NaCl,1 mM ZnCl2,10 % Glycerol, pH 7.5.

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Détail du antigène

Antigène: CPE (Carboxypeptidase E (CPE))

Autre désignation: Carboxypeptidase E/CPE

Sujet:

Background: The active form of CPE cleaves C-terminal amino acid residues of the peptide, and is thus involved in the biosynthesis of peptide hormones and neurotransmitters including insulin, enkephalin, etc. It is thought that membrane-associated CPE acts as a sorting receptor for targeting regulated secretory proteins which are mostly prohormones and neuropeptides in the trans-Golgi network of the pituitary and in secretory granules into the secretory pathway. Defects in this protein are implicated in type II diabetes due to impaired glucose clearance and insulin resistance.

Synonym: Carboxypeptidase E(CPE for short), Carboxypeptidase H, Enkephalin convertase, Prohormone-processing carboxypeptidase

Poids moléculaire: 47.1 kDa

UniProt: P16870

Pathways: Peptide Hormone Metabolism, Synaptic Membrane