CRADD Protein (AA 1-199)

N° du produit ABIN7319673

Protéine Recombinant CRADD exprimée dans Escherichia coli (E. coli).

Aperçu rapide pour CRADD Protein (AA 1-199) (ABIN7319673)

Antigène: CRADD (CASP2 and RIPK1 Domain Containing Adaptor with Death Domain (CRADD))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Pureté: > 95 % as determined by reducing SDS-PAGE.

Détail du produit

Attributs du protein: AA 1-199

Fonction: Recombinant Human CRADD/RAIDD Protein

Séquence: Met1-Glu199

Attributs du produit: Recombinant Human CRADD is produced by our E.coli expression system and the target gene encoding Met1-Glu199 is expressed.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: CRADD (CASP2 and RIPK1 Domain Containing Adaptor with Death Domain (CRADD))

Autre désignation: CRADD/RAIDD

Sujet: CRADD,Caspase and RIP Adapter with Death Domain,Death Domain-Containing Protein CRADD,RAIDD,RIP-Associated Protein with A Death Domain,Death Domain-Containing Protein CRADD (CRADD) is widely expressed in most tissues, with particularly high expression in the adult heart, testis, liver, skeletal muscle, fetal liver, and kidney. CRADD contains one CARD domain that mediates the interaction with caspase-2, and one death domain involved in the binding of RIP protein. CRADD functions as an apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. CRADD induces cell apoptosis/cell death in numerous tissues. Defects in CRADD will result in mental retardation.

Poids moléculaire:

Calculated MW: 23 kDa

Observed MW: 21 kDa

ID gène: 8738

UniProt: P78560

Pathways: Apoptose, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity