CD40 Protein (CD40) (AA 21-193) (His tag)

N° du produit ABIN7320973

Cette protéine Recombinant CD40 est produite dans HEK-293 Cells.

Aperçu rapide pour CD40 Protein (CD40) (AA 21-193) (His tag) (ABIN7320973)

Antigène: CD40

Type de proteíne: Recombinant

Origine: Cynomolgus

Source: HEK-293 Cells

Pureté: > 95 % as determined by reducing SDS-PAGE.

Détail du produit

Attributs du protein: AA 21-193

Purification/Conjugué: Cette CD40 protéine est marqué à la His tag.

Fonction: Recombinant Cynomolgus CD40/TNFRSF5/CD40L receptor Protein (His Tag)

Séquence: Glu21-Arg193

Attributs du produit: Recombinant Cynomolgus CD40 is produced by our Mammalian expression system and the target gene encoding Glu21-Arg193 is expressed with a 6His tag at the C-terminus.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: CD40

Autre désignation: CD40/TNFRSF5/CD40L receptor

Sujet: B-Cell Surface Antigen CD40,Bp50,CD40,CD40L Receptor,CDw40,TNFRSF5,Tumor Necrosis Factor Receptor Superfamily member 5,CD40 is a Type I Transmembrane Glycoprotein that belongs to the TNF Receptor Superfamily. CD40 is expressed in B cells, follicular dendritic cells, dendritic cells, activated monocytes, macrophages, endothelial cells, vascular smooth muscle cells, and several tumor cell lines. The extracellular domain of CD40 is characterized by Cysteine rich repeat regions. Interaction of CD40 with its ligand (CD40L) leads to aggregation of CD40 Molecules, which in turn interact with cytoplasmic components to initiate signaling pathways. Several different TRAF proteins (adaptor proteins) have been identified to serves as mediators of the signal transduction.

Poids moléculaire:

Calculated MW: 20.2 kDa

Observed MW: 28-30 kDa

UniProt: G7PG38

Pathways: Signalisation NF-kappaB, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints