CD47 Protein (CD47) (His tag)

N° du produit ABIN7319534

Cette protéine Recombinant CD47 est exprimée dans Human Cells.

Aperçu rapide pour CD47 Protein (CD47) (His tag) (ABIN7319534)

Antigène: CD47

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: Human Cells

Pureté: > 95 % as determined by reducing SDS-PAGE.

Détail du produit

Purification/Conjugué: Cette CD47 protéine est marqué à la His tag.

Fonction: Recombinant Human CD47/IAP Protein (His Tag)(Active)

Séquence: Gln19-Pro139

Attributs du produit: Recombinant Human CD47 is produced by our Mammalian expression system and the target gene encoding Gln19-Pro139 is expressed with a 6His tag at the C-terminus.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: Immobilized Human SIRPA-Fc(Cat: PKSH033061) at 10μg/ml(100 μl/well) can bind Human CD47-His. The ED50 of Human CD47-His is 4.18 ng/ml .

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 10 mM Tris-Citrate, 150 mM NaCl, pH 8.0.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: CD47

Autre désignation: CD47/IAP

Sujet:

Background: CD47(Integrin-Associated Protein,IAP) is a 40 - 60 kDa variably glycosylated atypical member of the immunoglobulin superfamily. The ubiquitously expressed CD47 binds to SIRP family members on macrophages, neutrophils, and T cells. CD47 is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The protein is also a receptor for the C-terminal cell-binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This protein has broad tissue distribution, and is reduced in expression on Rh erythrocytes.

Synonym: Leukocyte Surface Antigen CD47, Antigenic Surface Determinant Protein OA3, Integrin-Associated Protein, IAP, Protein MER6, CD47, MER6

Poids moléculaire: 14.76 kDa

UniProt: Q08722