EPH Receptor A2 Protein (EPHA2) (AA 585-976) (His-GST)

N° du produit ABIN7317048

Cette protéine Recombinant EPH Receptor A2 est exprimée dans Baculovirus infected Insect Cells.

Aperçu rapide pour EPH Receptor A2 Protein (EPHA2) (AA 585-976) (His-GST) (ABIN7317048)

Antigène: EPH Receptor A2 (EPHA2)

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: Baculovirus infected Insect Cells

Pureté: > 95 % as determined by reducing SDS-PAGE.

Détail du produit

Attributs du protein: AA 585-976

Purification/Conjugué: Cette EPH Receptor A2 protéine est marqué à la His-GST.

Fonction: Recombinant Human EphA2 Protein (aa 585-976, His & GST Tag)

Séquence: Leu 585-Ile 976

Attributs du produit: A DNA sequence encoding the human EPHA2 (P29317) (Leu585-Ile976) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: The specific activity was determined to be 50 nmol/min/mg using Poly(Glu:Tyr) 4:1 as substrate.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Supplied as sterile solution of 20 mM Tris, 500 mM NaCl, 3 mM DTT, pH 8.5, 10 % glycerol

Agent conservateur: Dithiothreitol (DTT)

Précaution d'utilisation: This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Date de péremption: 6 months

Détail du antigène

Antigène: EPH Receptor A2 (EPHA2)

Autre désignation: EphA2

Sujet: ARCC2,CTPA,CTPP1,CTRCT6,ECK,EPHA2,Ephrin type-A receptor 2,Epithelial cell kinase,Tyrosine-protein kinase receptor ECK,Eph receptor A2 is a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. The Eph receptors' corresponding family of ligands are the ephrins anchored to cell surfaces. The ephrins and Eph receptors are implicated as positional labels that may guide the development of neural topographic maps. They have also been found implicated in embryonic patterning, neuronal targeting, vascular development and adult neovascularization. The large family of ligands and receptors may make a major contribution to the accurate spatial patterning of connections and cell position in the nervous system. Furthermore, elevated expression of Eph receptors and ephrin ligands is associated with tumors and associated tumor vasculature, suggesting the Eph receptors and ephrin ligands also play critical roles in tumor angiogenesis and tumor growth. Unlike most Eph kinases, which are primarily expressed during development, EphA2 is primarily found in adult human epithelial cells. The cellular functions of EphA2 may be regulating cell growth, survival, migration, and angiogenesis.Unlike other receptor tyrosine kinases, ligand binding is not necessary for EphA2. Rather, the ligand appears to regulate EphA2 subcellular localization and its interactions with downstream adapter and signaling proteins. Eph receptor A2(EphA2) has been demonstrated to critically regulate tumor cell growth, migration and invasiveness. Eph receptor A2(EphA2) is frequently overexpressed and functionally altered in aggressive tumor cells, and that these changes promote metastatic character.

Poids moléculaire:

Calculated MW: 72.1 kDa

Observed MW: 62 kDa

ID gène: 1969

UniProt: P29317

Pathways: Signalisation RTK