EPH Receptor A7 Protein (EPHA7) (AA 579-998) (His-GST)

N° du produit ABIN7317067

Protéine Recombinant EPH Receptor A7 exprimée dans Baculovirus infected Insect Cells.

Aperçu rapide pour EPH Receptor A7 Protein (EPHA7) (AA 579-998) (His-GST) (ABIN7317067)

Antigène: EPH Receptor A7 (EPHA7)

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: Baculovirus infected Insect Cells

Pureté: > 94 % as determined by reducing SDS-PAGE.

Détail du produit

Attributs du protein: AA 579-998

Purification/Conjugué: Cette EPH Receptor A7 protéine est marqué à la His-GST.

Fonction: Recombinant Human EphA7/EHK3 Protein (His & GST Tag)

Séquence: Gly579-Val998

Attributs du produit: A DNA sequence encoding the human EPHA7 (NP_004431) (Gly579-Val998) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: The specific activity was determined to be 9.5 nmol/min/mg using Poly(Glu:Tyr) 4:1 as substrate.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Supplied as sterile solution of 20 mM Tris, 500 mM NaCl, pH 8.0, 10 % glycerol

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Date de péremption: 6 months

Détail du antigène

Antigène: EPH Receptor A7 (EPHA7)

Autre désignation: EphA7/EHK3

Sujet: EHK-3,EHK3,EK11,EPH Homology Kinase 3,EPH-Like Kinase 11,EPHA7,Ephrin Type-A Receptor 7,HEK11,hEK11,Ephrin type-A receptor 7, also known as EphA7, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHA9, EPHA10, EPHB1, EPHB2, EPHB3, EPHB4, EPHB5, EPHB6. The Eph family of receptor tyrosine kinases (comprising EphA and EphB receptors) has been implicated in synapse formation and the regulation of synaptic function and plasticity6. Eph receptor-mediated signaling, which is triggered by ephrins7, probably modifies the properties of synapses during synaptic activation and remodeling. Ephrin receptors are components of cell signalling pathways involved in animal growth and development, forming the largest sub-family of receptor tyrosine kinases (RTKs). Ligand-mediated activation of Ephs induce various important downstream effects and Eph receptors have been studied for their potential roles in the development of cancer. Down-regulation of EphA7 secondary to hypermethylation has been reported in colorectal cancer. The expression of EphA7 was reduced in all tested gastric cancer cell lines, however, there is marked variability in expression among gastric carcinoma specimens. EphA7 may have roles in the pathogenesis and development of gastric carcinomas.

Poids moléculaire:

Calculated MW: 75.2 kDa

Observed MW: 76 kDa

ID gène: 2045

NCBI Accession: NP_004431

UniProt: Q15375

Pathways: Signalisation RTK