EPH Receptor B4 Protein (EPHB4) (AA 563-987) (His-GST)

N° du produit ABIN7317112

Cette protéine Recombinant EPH Receptor B4 est exprimée dans Baculovirus infected Insect Cells.

Aperçu rapide pour EPH Receptor B4 Protein (EPHB4) (AA 563-987) (His-GST) (ABIN7317112)

Antigène: EPH Receptor B4 (EPHB4)

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: Baculovirus infected Insect Cells

Pureté: > 90 % as determined by reducing SDS-PAGE.

Détail du produit

Attributs du protein: AA 563-987

Purification/Conjugué: Cette EPH Receptor B4 protéine est marqué à la His-GST.

Fonction: Recombinant Human EphB4/HTK Protein (aa 563-987, His & GST Tag)

Séquence: Leu563-Tyr987

Attributs du produit: A DNA sequence encoding the human EPHB4 (P54760) (Leu563-Tyr987) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: The specific activity was determined to be 47 nmol/min/mg using Poly(Glu:Tyr) 4:1 as substrate.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Supplied as sterile solution of 20 mM Tris, 500 mM NaCl, pH 8.0, 3 mM DTT, 10 % glycerol

Agent conservateur: Dithiothreitol (DTT)

Précaution d'utilisation: This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Date de péremption: 6 months

Détail du antigène

Antigène: EPH Receptor B4 (EPHB4)

Autre désignation: EphB4/HTK

Sujet: HTK,MYK1,TYRO11,Ephrin type-B receptor 4 is a protein that in humans is encoded by the EPHB4 gene. It is a single-pass type I membrane protein belonging to the ephrin receptor subfamily of protein kinase superfamily. Members of the ephrin and Eph family are local mediators of cell function through largely contact-dependent processes in development and in maturity. Furthermore, EphB4 protein and the corresponding ligand Ephrin-B2 contribute to tumor growth in various human tumors. EphB4 protein has tumor suppressor activities and that regulation of cell proliferation, extracellular matrix remodeling, and invasive potential are important mechanisms of tumor suppression. Therefore, Ephrin-B2/EphB4 may be recognized as a novel prognostic indicator for cancers.

Poids moléculaire:

Calculated MW: 75.2 kDa

Observed MW: 66 kDa

ID gène: 2050

UniProt: P54760

Pathways: Signalisation RTK