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HMOX1 Protéine

Cette protéine Recombinant HMOX1 est produite dans Escherichia coli (E. coli).
N° du produit ABIN7318568
287,60 €
Plus frais de livraison 40,00 € et TVA
Destination: France
Envoi sous 9 à 13 jours ouvrables

Aperçu rapide pour HMOX1 Protéine (ABIN7318568)

Antigène

Voir toutes HMOX1 Protéines
HMOX1 (Heme Oxygenase (Decycling) 1 (HMOX1))

Type de proteíne

Recombinant

Origine

  • 15
  • 4
  • 4
  • 4
  • 2
  • 1
  • 1
Humain

Source

  • 17
  • 6
  • 3
  • 2
  • 2
  • 1
Escherichia coli (E. coli)

Pureté

> 95 % as determined by reducing SDS-PAGE.
  • Fonction

    Recombinant Human HO-1/HMOX1 Protein

    Séquence

    Met 1-Thr 261

    Attributs du produit

    Recombinant Human Heme Oxygenase 1 is produced by our E.coli expression system and the target gene encoding Met1-Thr261 is expressed.

    niveau d'endotoxine

    < 1.0 EU per μg as determined by the LAL method.
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  • Restrictions

    For Research Use only
  • Format

    Frozen, Liquid

    Buffer

    Supplied as a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, 1 mM EDTA, pH 7.4.

    Stock

    -20 °C

    Stockage commentaire

    Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
  • Antigène

    HMOX1 (Heme Oxygenase (Decycling) 1 (HMOX1))

    Autre désignation

    HO-1/HMOX1

    Sujet

    Background: Heme Oxygenase 1 (HO-1) is an enzyme in endoplasmic reticulum that belongs to the heme oxygenase family. HO-1 cleaves the heme ring at the alpha methene bridge to form Biliverdin. Biliverdin is subsequently converted to Bilirubin by Biliverdin reductase. In physiological state, the highest activity of HO-1 is found in the spleen, where senescent erythrocytes are sequestrated and destroyed. HO-1 activity is highly inducible by its substrate heme and by various non-heme substances such as heavy metals, bromobenzene, endotoxin, oxidizing agents and UVA. HO-1 is involved in the regulation of cardiovascular function and response to a variety of stressors. Defects in HO-1 are the cause of Heme Oxygenase 1 deficiency, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues.

    Synonym: Heme Oxygenase 1, HO-1, HMOX1, HO, HO1

    Poids moléculaire

    29.9 kDa

    UniProt

    P09601

    Pathways

    Transition Metal Ion Homeostasis, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, SARS-CoV-2 Protein Interactome
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