IL1A Protéine

N° du produit ABIN7321259

Protéine Recombinant IL1A exprimée dans Escherichia coli (E. coli).

Aperçu rapide pour IL1A Protéine (ABIN7321259)

Antigène: IL1A (Interleukin 1 alpha (IL1A))

Type de proteíne: Recombinant

Origine: Rat

Source: Escherichia coli (E. coli)

Pureté: > 95 % as determined by SDS-PAGE

Détail du produit

Fonction: Recombinant Rat IL-1A/ IL-1α Protein

Séquence: Ser115-Ser270

Attributs du produit: Recombinant Rat Interleukin-1 Alpha is produced by our E.coli expression system and the target gene encoding Ser115-Ser270 is expressed.

niveau d'endotoxine: <1.0 EU per μg as determined by LAL test.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: IL1A (Interleukin 1 alpha (IL1A))

Autre désignation: IL-1A/ IL-1alpha

Sujet:

Background: Interleukin 1 (IL-1) is a name that designates two proteins, IL-1αand IL-1β, which are the products of distinct genes, but which show approximately 25 % amino acid (aa) sequence identity and which recognize the same cell surface receptors. IL-1αand IL-1β are both synthesized as 31 kDa precursors that are subsequently cleaved into proteins with molecular weights of approximately 17,000 Da. Neither precursor contains a typical hydrophobic signal peptide sequence and most of the precursor form of IL-1α remains in the cytosol of cells, although there is evidence for a membranebound form of the precursor form of IL-1α. Although IL-1 production is generally considered to be a consequence of inflammation, evidence suggests that IL-1 is also temporally upregulated during bone formation and the menstrual cycle and can be induced in response to nervous system stimulation. In response to classic stimuli produced by inflammatory agents, infections or microbial endotoxins, a dramatic increase in the production of IL-1 by macrophages and various other cells is seen.

Synonym: Interleukin-1 alpha, IL-1 alpha, Il1a

Poids moléculaire: 17.9 kDa

UniProt: P16598

Pathways: Signalisation NF-kappaB, Autophagy, Cancer Immune Checkpoints