JAG1 Protein (Fc Tag)

N° du produit ABIN7319310

Cette protéine Recombinant JAG1 est exprimée dans Human Cells.

Aperçu rapide pour JAG1 Protein (Fc Tag) (ABIN7319310)

Antigène: JAG1 (Jagged 1 (JAG1))

Type de proteíne: Recombinant

Origine: Humain

Source: Human Cells

Pureté: > 90 % as determined by reducing SDS-PAGE.

Détail du produit

Purification/Conjugué: Cette JAG1 protéine est marqué à la Fc Tag.

Fonction: Recombinant Human Jagged 1/JAG1 Protein (Fc Tag)

Séquence: Gln34-Ser1046

Attributs du produit: Recombinant Human jagged-1 is produced by our Mammalian expression system and the target gene encoding Gln34-Ser1046 is expressed with a Fc tag at the C-terminus.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: JAG1 (Jagged 1 (JAG1))

Autre désignation: Jagged 1/JAG1

Sujet:

Background: Protein jagged-1 I, also known as Jagged-1, JAGL1, HJ1, JAG1 and CD339, is a single-pass type I membrane protein. JAG1 contains one DSL domain and sixteen EGF-like domain. JAG1 acts as a ligand for multiple Notch receptors and is involved in the mediation of Notch signaling. JAG1 may participate in early and late stages of mammalian cardiovascular development, JAG1 inhibits myoblast differentiation and enhances fibroblast growth factor-induced angiogenesis. Defects in JAG1 are the cause of Alagille syndrome type 1, which is autosomal dominant multisystem disorder defined clinically by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal, and ophthalmologic manifestations.

Synonym: Protein jagged-1 I, Jagged-1, JAGL1, HJ1, JAG1 and CD339,AGS,AHD,AWS,Jagged 1

Poids moléculaire: 138.5 kDa

NCBI Accession: NP_000205

Pathways: Signalisation Notch, Stem Cell Maintenance