Pleiotrophin Protein (PTN) (Fc Tag)

N° du produit ABIN7320076

Cette protéine Recombinant Pleiotrophin est exprimée dans HEK-293 Cells.

Aperçu rapide pour Pleiotrophin Protein (PTN) (Fc Tag) (ABIN7320076)

Antigène: Pleiotrophin (PTN)

Type de proteíne: Recombinant

Origine: Souris

Source: HEK-293 Cells

Pureté: > 85 % as determined by SDS-PAGE

Détail du produit

Purification/Conjugué: Cette Pleiotrophin protéine est marqué à la Fc Tag.

Fonction: Recombinant Mouse Pleiotrophin/PTN/HB-GAM Protein (Fc Tag)

Séquence: Gly 33-Asp 168

Attributs du produit: A DNA sequence encoding the mouse PTN (P63089) (Gly 33-Asp 168) was fused with the Fc region of human IgG1 at the N-terminus.

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: Pleiotrophin (PTN)

Autre désignation: Pleiotrophin/PTN/HB-GAM

Sujet:

Background: HB-GAM belongs to the pleiotrophin family. During embryonic and early postnatal development, HB-GAM is expressed in the central and peripheral nervous system and also in several non-neural tissues, notably lung, kidney, gut and bone. While in the adult central nervous system, it is expressed in an activity-dependent manner in the hippocampus where it can suppress long term potentiation induction. HB-GAM has a low expression in other areas of the adult brain, but it can be induced by ischemic insults, or targeted neuronal damaged in the entorhinal cortex or in the substantia nigra pars compacta. It is structurally related to midkine and retinoic acid induced heparin-binding protein and has a high affinity for heparin. HB-GAM binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation. It also functions as a secreted growth factor and induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells.

Synonym: Pleiotrophin, PTN, Heparin-binding brain mitogen, HBBM, Heparin-binding growth factor 8, HBGF-8, Osteoblast-specific factor 1, OSF-1,HARP,HB-GAM,HBBN,HBNF,OSF,Osf-1,Osf1

Poids moléculaire: 43.7 kDa

UniProt: P63089

Pathways: Signalisation RTK