Podoplanin Protein (PDPN) (His tag)

N° du produit ABIN7320345

Protéine Recombinant Podoplanin exprimée dans Baculovirus infected Insect Cells.

Aperçu rapide pour Podoplanin Protein (PDPN) (His tag) (ABIN7320345)

Antigène: Podoplanin (PDPN)

Type de proteíne: Recombinant

Origine: Souris

Source: Baculovirus infected Insect Cells

Pureté: > 92 % as determined by reducing SDS-PAGE.

Détail du produit

Purification/Conjugué: Cette Podoplanin protéine est marqué à la His tag.

Fonction: Recombinant Mouse Podoplanin/PDPN Protein (His Tag)

Séquence: Met 1-Lys 133

Attributs du produit: A DNA sequence encoding the mouse PDPN N-terminal fragment (NP_034459.2) (Met 1-Lys 133) was expressed,with a C-terminal polyhistidine tag.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: Podoplanin (PDPN)

Autre désignation: Podoplanin/PDPN

Sujet: Aggrus,Glycoprotein 38,Gp38,OTS-8,PA2.26 antigen,Podoplanin,RANDAM-2,T1-alpha,T1a,T1alpha,Podoplanin, also known asPDPN, is a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined. Alternatively spliced transcript variants encoding different isoforms have been identified.PDPN is a mucin-type glycoprotein negatively charged by extensive O-glycosylation and a high content of sialic acid, which expresses the adhesive property. It is selectively expressed in lymphatic endothelium as well as lymphangiomas, Kaposi sarcomas, and in a subset of angiosarcomas with probable lymphatic differentiation. PDPN may contribute to form odontoblastic fiber or function as the anchorage to the tooth development and in proliferating epithelial cells of cervical loop and apical bud. The intensity of podoplanin expression is negatively correlated with the expression of CD34 and factor VIII. Podoplanin would be useful as a diagnostic marker for epithelioid hemangioendothelioma in liver tumors.

Poids moléculaire:

Calculated MW: 13 kDa

Observed MW: 25 kDa

ID gène: 14726

NCBI Accession: NP_034459

UniProt: Q62011

Pathways: Dicarboxylic Acid Transport