Prolactin Protein (PRL) (His tag)

N° du produit ABIN7318933

Cette protéine Recombinant Prolactin est produite dans Human Cells.

Aperçu rapide pour Prolactin Protein (PRL) (His tag) (ABIN7318933)

Antigène: Prolactin (PRL)

Type de proteíne: Recombinant

Origine: Humain

Source: Human Cells

Pureté: > 95 % as determined by reducing SDS-PAGE.

Détail du produit

Purification/Conjugué: Cette Prolactin protéine est marqué à la His tag.

Fonction: Recombinant Human Prolactin/PRL Protein (His Tag)

Séquence: Leu29-Cys227

Attributs du produit: Recombinant Human Prolactin is produced by our Mammalian expression system and the target gene encoding Leu29-Cys227 is expressed with a 6His tag at the C-terminus.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: Prolactin (PRL)

Autre désignation: Prolactin/PRL

Sujet:

Background: Prolactin (PRL) is a secreted neuroendocrine pituitary hormone that acts primarily on the mammary gland to promote lactation, but has pleiotropic effects in both males and females. Non-glycosylated prolactin is produced by the pituitary and packaged in storage granules before secretion, while glycosylated prolactin is reported to be constitutively secreted, have lower biological potency, and be removed from the circulation more quickly. Prolactin is synthesized mainly by the anterior pituitary in all mammals, where secretion is under tonic inhibition by hypothalamic dopamine. In humans, prolactin is also produced peripherally. Prolactin expression is low during early human pregnancy, but increases in late pregnancy. The prolactin receptor (PRLR) is a transmembrane type I glycoprotein that belongs to the cytokine hematopoietic receptor family. prolactin molecule is thought to bind two receptor molecules. In addition to its lactogenic activity, peripherally produced prolactin plays roles in breast and prostate cancer development, regulation of reproductive function, and immunoregulation.

Synonym: Prolactin, PRL

Poids moléculaire: 23.9 kDa

UniProt: P01236

Pathways: Signalistation JAK/STAT, Peptide Hormone Metabolism, Response to Growth Hormone Stimulus, Protein targeting to Nucleus