PTK6 Protein (AA 1-451) (His-GST)

N° du produit ABIN7320007

Protéine Recombinant PTK6 exprimée dans Baculovirus infected Insect Cells.

Aperçu rapide pour PTK6 Protein (AA 1-451) (His-GST) (ABIN7320007)

Antigène: PTK6 (PTK6 Protein tyrosine Kinase 6 (PTK6))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Souris

Source: Baculovirus infected Insect Cells

Pureté: > 90 % as determined by reducing SDS-PAGE.

Détail du produit

Attributs du protein: AA 1-451

Purification/Conjugué: Cette PTK6 protéine est marqué à la His-GST.

Fonction: Recombinant Mouse PTK6/Brk Protein (His & GST Tag)

Séquence: Met1-Val451

Attributs du produit: A DNA sequence encoding the mouse PTK6 (Q64434) (Met1-Val451) was expressed with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: The specific activity was determined to be 5 nmol/min/mg using poly [Glu, Tyr] 4:1 as substrate.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Supplied as sterile solution of 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Date de péremption: 6 months

Détail du antigène

Antigène: PTK6 (PTK6 Protein tyrosine Kinase 6 (PTK6))

Autre désignation: PTK6/Brk

Sujet: BRK,Sik,Tksk,tks,Tyrosine kinase (PTKs) is a protein that carry out tyrosine phosphorylation, which play a fundamental role in cell proliferation, survival, adhesion, and motility and have also been demenstrated to mediate malignant cell transformation. Overexpression of this protein in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Two classes of PTKs are present in cells: the transmembrane receptor PTKs and the non-receptor PTKs. Tyrosine kinase(PTKs)-6/ BRK is a cytoplasmic non-receptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Tyrosine kinase(PTKs)-6/ BRK has been shown to undergo autophosphorylation. It has been found that the constitutive expression of the tyrosine kinase(PTKs)-6/ BRK is in a large proportion of cutaneous T-cell lymphomas and other transformed T- and B-cell populations. State BRK expression was also induced in normal T-cells. In clinical, the cytoplasmic tyrosine kinase PTK6 (BRK) shows elevated expression in approximately two-thirds of primary breast tumours, and is implicated in EGF receptor-dependent signalling and epithelial tumorigenesis.

Poids moléculaire:

Calculated MW: 79.8 kDa

Observed MW: 66 kDa

UniProt: Q64434