PTK6 Protein (GST tag)

N° du produit ABIN7317095

Détail du produit

Antigène: PTK6 (PTK6 Protein tyrosine Kinase 6 (PTK6))

Type de proteíne: Recombinant

Origine: Humain

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette PTK6 protéine est marqué à la GST tag.

Fonction: Recombinant Human PTK6/Brk Protein (GST Tag)

Séquence: Met 1-Thr 451

Attributs du produit: A DNA sequence encoding the full length of human PTK6 (NP_005966.1) (Met 1-Thr 451) was fused with the GST tag at the N-terminus.

Pureté: > 89 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Frozen, Liquid

Buffer: Supplied as sterile 50 mM Tris, 100 mM NaCl, pH 8.0, 10 % glycerol

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Détail du antigène

Antigène: PTK6 (PTK6 Protein tyrosine Kinase 6 (PTK6))

Autre désignation: PTK6/Brk (PTK6 Produits)

Synonymes: BRK Protein, Sik Protein, Tksk Protein, tks Protein, zgc:153964 Protein, protein tyrosine kinase 6 Protein, PTK6 protein tyrosine kinase 6 Protein, PTK6 protein tyrosine kinase 6b Protein, PTK6 Protein, Ptk6 Protein, ptk6b Protein

Sujet:

Background: Tyrosine kinase (PTKs) is a protein that carry out tyrosine phosphorylation, which play a fundamental role in cell proliferation, survival, adhesion, and motility and have also been demenstrated to mediate malignant cell transformation. Overexpression of this protein in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Two classes of PTKs are present in cells: the transmembrane receptor PTKs and the non-receptor PTKs. Tyrosine kinase(PTKs)-6/ BRK is a cytoplasmic non-receptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Tyrosine kinase(PTKs)-6/ BRK has been shown to undergo autophosphorylation. It has been found that the constitutive expression of the tyrosine kinase(PTKs)-6/ BRK is in a large proportion of cutaneous T-cell lymphomas and other transformed T- and B-cell populations. State BRK expression was also induced in normal T-cells. In clinical, the cytoplasmic tyrosine kinase PTK6 (BRK) shows elevated expression in approximately two-thirds of primary breast tumours, and is implicated in EGF receptor-dependent signalling and epithelial tumorigenesis.

Synonym: BRK

Poids moléculaire: 78 kDa

NCBI Accession: NP_005966