RNASET2 Protein (His tag)

N° du produit ABIN7319474

Cette protéine Recombinant RNASET2 est produite dans Human Cells.

Aperçu rapide pour RNASET2 Protein (His tag) (ABIN7319474)

Antigène: RNASET2 (Ribonuclease T2 (RNASET2))

Type de proteíne: Recombinant

Origine: Humain

Source: Human Cells

Pureté: > 95 % as determined by reducing SDS-PAGE.

Détail du produit

Purification/Conjugué: Cette RNASET2 protéine est marqué à la His tag.

Fonction: Recombinant Human RNASET2 Protein (Human Cells, His Tag)

Séquence: Asp25-His256

Attributs du produit: Recombinant Human Ribonuclease T2 is produced by our Mammalian expression system and the target gene encoding Asp25-His256 is expressed with a 6His tag at the C-terminus.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM TrisHcl, 150 mM NaCl,20 % Glycerol, pH 7.5.

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Détail du antigène

Antigène: RNASET2 (Ribonuclease T2 (RNASET2))

Autre désignation: RNASET2

Sujet:

Background: RNASET2 (ribonuclease T2) is an enzyme which belongs to the RNase T2 family. It is highly expressed in the temporal lobe and fetal brain. RNASET2 gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. This protein can be inhibited by Zn2+ and Cu2+. It has ribonuclease activity, with higher activity at acidic pH and is probably involved in lysosomal degradation of ribosomal RNA. Defects in RNASET2 are the cause of leukoencephalopathy cystic without megalencephaly. An infantile-onset syndrome of cerebral leukoencephalopathy. Affected newborns develop microcephaly and neurologic abnormalities including psychomotor impairment, seizures and sensorineural hearing impairment. The brain shows multifocal white matter lesions, anterior temporal lobe subcortical cysts, pericystic abnormal myelination, ventriculomegaly and intracranial calcifications.

Synonym: Ribonuclease T2,3.1.27.-,Ribonuclease 6,RNASE6PL

Poids moléculaire: 28.2 kDa

UniProt: O00584