RNASET2 Protein (His tag)

N° du produit ABIN7319474

Détail du produit

Antigène: RNASET2 (Ribonuclease T2 (RNASET2))

Type de proteíne: Recombinant

Origine: Humain

Source: Human Cells

Purification/Conjugué: Cette RNASET2 protéine est marqué à la His tag.

Fonction: Recombinant Human RNASET2 Protein (Human Cells, His Tag)

Séquence: Asp25-His256

Attributs du produit: Recombinant Human Ribonuclease T2 is produced by our Mammalian expression system and the target gene encoding Asp25-His256 is expressed with a 6His tag at the C-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM TrisHcl, 150 mM NaCl,20 % Glycerol, pH 7.5.

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Détail du antigène

Antigène: RNASET2 (Ribonuclease T2 (RNASET2))

Autre désignation: RNASET2 (RNASET2 Produits)

Synonymes: RNASE6PL Protein, bA514O12.3 Protein, MGC83874 Protein, MGC145364 Protein, dre2 Protein, wu:fc10c06 Protein, zgc:113369 Protein, ribonuclease T2 Protein, ribonuclease T2 L homeolog Protein, ribonuclease t2 Protein, RNASET2 Protein, Rnaset2 Protein, rnaset2.L Protein, rnaset2 Protein, TM1040_2631 Protein, RPE_1409 Protein, Bind_1696 Protein, Dd586_2225 Protein, Nhal_0810 Protein, Snov_2442 Protein, Fbal_2689 Protein, Nitsa_0808 Protein, Mesop_3495 Protein

Sujet:

Background: RNASET2 (ribonuclease T2) is an enzyme which belongs to the RNase T2 family. It is highly expressed in the temporal lobe and fetal brain. RNASET2 gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. This protein can be inhibited by Zn2+ and Cu2+. It has ribonuclease activity, with higher activity at acidic pH and is probably involved in lysosomal degradation of ribosomal RNA. Defects in RNASET2 are the cause of leukoencephalopathy cystic without megalencephaly. An infantile-onset syndrome of cerebral leukoencephalopathy. Affected newborns develop microcephaly and neurologic abnormalities including psychomotor impairment, seizures and sensorineural hearing impairment. The brain shows multifocal white matter lesions, anterior temporal lobe subcortical cysts, pericystic abnormal myelination, ventriculomegaly and intracranial calcifications.

Synonym: Ribonuclease T2,3.1.27.-,Ribonuclease 6,RNASE6PL

Poids moléculaire: 28.2 kDa

UniProt: O00584