S100A12 Protéine

N° du produit ABIN7317645

Cette protéine Recombinant S100A12 est produite dans Escherichia coli (E. coli).

Aperçu rapide pour S100A12 Protéine (ABIN7317645)

Antigène: S100A12 (S100 Calcium Binding Protein A12 (S100A12))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: Escherichia coli (E. coli)

Application: ELISA

Pureté: > 98 % as determined by reducing SDS-PAGE.

Détail du produit

Fonction: Recombinant Human S100A12/CAGC Protein

Séquence: Met 1-Glu 92

Attributs du produit: A DNA sequence encoding the native human S100A12 (NP_005612.1) (Met 1-Glu 92) was expressed.

Stérilité: 0.2 μm filtered

Biological Activity Comment: Immobilized recombinant human S100A12 at 2 μg/ml (100 μl/well) can bind human AGER with a linear range of 0.032-20 μg/ml.

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: S100A12 (S100 Calcium Binding Protein A12 (S100A12))

Autre désignation: S100A12/CAGC

Sujet: CGRP,Calcitermin,Calcium-binding protein in amniotic fluid 1,Calgranulin-C,EN-RAGE,Extracellular newly identified RAGE-binding protein,MRP-6,Migration inhibitory factor-related protein 6,Protein S100-A12,S100 calcium-binding protein A12,S100A12,S100 proteinis a family of low molecular weight protein found in vertebrates characterized by twoEF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that the protein is100 % soluble in ammonium sulfateat neutral pH . Most S100 proteins are disulfide-linked homodimer, and is normally present in cells derived from theneural crest, chondrocytes, macrophages, dendritic cells, etc. S100 proteins have been implicated in a variety of intracellular and extracellular functions. They are involved in regulation of protein phosphorylation, transcription factors, the dynamics of cytoskeleton constituents, enzyme activities, cell growth and differentiation, and the inflammatory response. Protein S100-A12, also known as S100 calcium-binding protein A12, Calcium-binding protein in amniotic fluid 1, Calgranulin-C, and S100A12, is a member of the S-101 family. Like the majority of S100 proteins, S100A12 is a dimer, with the interface between the two subunits being composed mostly of hydrophobic residues. The fold of S100A12 is similar to the other known crystal and solution structures of S100 proteins, except for the linker region between the two EF-hand motifs. S100A12 plays an important role in the inflammatory response.

Poids moléculaire:

Calculated MW: 10.6 kDa

Observed MW: 10 kDa

ID gène: 6283

NCBI Accession: NP_005612

UniProt: P80511

Pathways: Toll-Like Receptors Cascades, S100 Proteins