Sclerostin Protein (SOST) (His tag)

N° du produit ABIN7320639

Cette protéine Recombinant Sclerostin est produite dans Human Cells.

Aperçu rapide pour Sclerostin Protein (SOST) (His tag) (ABIN7320639)

Antigène: Sclerostin (SOST)

Type de proteíne: Recombinant

Origine: Souris

Source: Human Cells

Pureté: > 90 % as determined by SDS-PAGE

Détail du produit

Purification/Conjugué: Cette Sclerostin protéine est marqué à la His tag.

Fonction: Recombinant Mouse Sclerostin/SOST Protein (His Tag)

Séquence: Gln24-Tyr211

Attributs du produit: Recombinant Mouse Sclerostin is produced by our Mammalian expression system and the target gene encoding Gln24-Tyr211 is expressed with a 6His tag at the C-terminus.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: Sclerostin (SOST)

Autre désignation: Sclerostin/SOST

Sujet:

Background: Sclerostin (SOST) is a member of the cerberus/DAN family, a group of secreted glycoproteins characterized by a cysteine-knot motif. Cerberus/DAN family members are putative BMP antagonists, and include Dan, Cerberus, Gremlin, PRDC, and Caronte. While the overall sequence identity between members of the family is low, they have conserved spacing of six cysteine residues. Cerberus and Dan have an additional cysteine residue used for dimerization? however, SOST does not and is secreted as a monomer. SOST was originally identified as an important regulator of bone homeostasis. SOST is expressed by osteoclasts in developing bones of mouse embryos, including both intramembranously forming skull bones and endochondrally forming long bones. SOST plays a physiological role as a negative regulator of bone formation by repressing BMP-induced osteogenesis. SOST has been shown to have unique ligand specificity, binding BMP-5, -6, and -7 with high affinity and BMP-2 and -4 with low affinity.

Synonym: Sclerostin, Sost

Poids moléculaire: 21.9 kDa

UniProt: Q99P68