SNCA Protein (AA 1-140)

N° du produit ABIN7320688

Protéine Recombinant SNCA exprimée dans Escherichia coli (E. coli).

Aperçu rapide pour SNCA Protein (AA 1-140) (ABIN7320688)

Antigène: SNCA (Synuclein, alpha (SNCA))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Souris

Source: Escherichia coli (E. coli)

Application: ELISA

Pureté: > 95 % as determined by reducing SDS-PAGE.

Détail du produit

Attributs du protein: AA 1-140

Fonction: Recombinant Mouse α-Synuclein/SNCA Protein

Séquence: Met1-Ala140

Attributs du produit: Recombinant Mouse alpha-Synuclein is produced by our E.coli expression system and the target gene encoding Met1-Ala140 is expressed.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Immobilized Recombinant Mouse SNCA(PKSM041187) at 2μg/ml (100 μl/well) can bind AAnti-Human SNCA antibody.The ED₅₀ of Anti-SNCA antibody is 4.65ng/ml.

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: SNCA (Synuclein, alpha (SNCA))

Autre désignation: alpha-Synuclein/SNCA

Sujet: Alpha-synuclein,NACP,Non-A beta component of AD amyloid,Non-A4 component of amyloid precursor,Snca,Alpha-Synuclein (SNCA) is a member of the Synuclein family. SNCA is expressed principally in brain but also expressed in low concentrations in all tissues except liver. SNCA interacts with UCHL1, Phospholipase D and histones. SNCA can include beta- and gamma-synuclein. In addition, SNCA is an important regulatory component of vesicular transport in neuronal cells. It has been suggested that SNCA is related to the pathogenesis of Parkinson's Disease and neurodegenerative disorders. Defects in SNCA will lead to Dementia Lewy Body (DLB).

Poids moléculaire:

Calculated MW: 14.5 kDa

Observed MW: 17 kDa

ID gène: 20617

UniProt: O55042

Pathways: Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity