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CD28 Protein (CD28) (Biotin)

CD28 Origine: Humain, Cynomolgus Hôte: Human Cells Recombinant >95 % as determined by reducing SDS-PAGE. Active
N° du produit ABIN7319852
  • Antigène Voir toutes CD28 Protéines
    CD28
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Origine
    • 21
    • 12
    • 8
    • 7
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain, Cynomolgus
    Source
    • 21
    • 5
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human Cells
    Purification/Conjugué
    Cette CD28 protéine est marqué à la Biotin.
    Fonction
    Recombinant Human/Cynomolyus CD28/TP44 (C-Fc-Avi) Biotinylated
    Séquence
    Asn19-Pro152
    Attributs du produit
    Biotinylated Recombinant Human T-cell-specific surface glycoprotein CD28 is produced by our Mammalian expression system and the target gene encoding Asn19-Pro152 is expressed with a Fc, Avi tag at the C-terminus.
    Pureté
    >95 % as determined by reducing SDS-PAGE.
    niveau d'endotoxine
    < 1.0 EU per μg as determined by the LAL method.
    Biological Activity Comment
    Immobilized  Anti-CD28 mAb(Cat#A063) at 2μg/ml (100 μl/well) can bind Human/Cynomolgus CD28-Fc-Avi(Cat#CY34). The ED50 of  Human/Cynomolgus CD28-Fc-Avi(Cat#CY34) is 0.84 ng/ml.
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    Discover our top product CD28 Protéine
  • Commentaires

    60-90 kDa

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from a 0.2 μm filtered solution of 20mTris-HCl, 150 mM NaCl, pH 8.0.
    Stock
    4 °C,-20 °C,-80 °C
    Stockage commentaire
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Antigène
    CD28
    Autre désignation
    CD28 (CD28 Produits)
    Synonymes
    Tp44 Protein, CD28RNA Protein, cd28 Protein, CD28 molecule Protein, CD28 antigen Protein, Cd28 molecule Protein, CD28 molecule L homeolog Protein, CD28 Protein, Cd28 Protein, cd28.L Protein
    Sujet

    Background: T-cell-specific surface glycoprotein CD28(CD28) is a single-pass typeI membrane protein which contains one Ig-likeV-type (immunoglobulin-like) domain. It belongs to the immunoglobulin(Ig) superfamily. CD28 is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation.CD28 co-stimulation is necessary for CD4 positive T-cell proliferation and survival, interleukin-2 production, and T-helper type-2 development. Human post-thymic regulatory T cells require CD28 co-stimulation to expand and maintain potent suppressive function in vivo. Apoptosis plays a key role in the age-related decline of CD28 expression and in immunosenescence. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2). When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells.

    Synonym: CD28, CD28 antigen, CD28 Molecule, T-cell-specific surface glycoprotein CD28, Tp44, TP44

    Poids moléculaire
    44.1 kDa
    UniProt
    P10747
    Pathways
    TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
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