HLAG Protein (AA 25-305, Monomer) (His-Avi Tag,Peptide (RIIPRHLQL))

N° du produit ABIN7274820

Cette protéine Recombinant HLAG est produite dans HEK-293 Cells.

Aperçu rapide pour HLAG Protein (AA 25-305, Monomer) (His-Avi Tag,Peptide (RIIPRHLQL)) (ABIN7274820)

Antigène: HLAG (HLA Class I Histocompatibility Antigen, alpha Chain G (HLAG))

Type de proteíne: Recombinant

Origine: Macaque rhésus

Source: HEK-293 Cells

Pureté: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Détail du produit

Attributs du protein: AA 25-305, Monomer

Purification/Conjugué: Cette HLAG protéine est marqué à la His-Avi Tag,Peptide (RIIPRHLQL).

Fonction: Rhesus macaque HLA-G&B2M&Peptide (RIIPRHLQL) Monomer Protein

Séquence: Gly25-Thr305(HLA-G), Ile21-Met119(B2M) and RIIPRHLQL peptide

Specificité: Uni-Prot: O02948 (HLA-G), Q6V7J5 (B2M), RIIPRHLQL

Attributs du produit: Recombinant Rhesus macaque HLA-G&B2M&Peptide (RIIPRHLQL) Monomer Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Gly25-Thr305 (HLA-G), Ile21-Met119 (B2M) and RIIPRHLQL peptide.

Stérilité: 0.22 μm filtered

niveau d'endotoxine: Less than 1EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Date de péremption: 12 months

Détail du antigène

Antigène: HLAG (HLA Class I Histocompatibility Antigen, alpha Chain G (HLAG))

Autre désignation: HLA-G

Sujet: HLA-G is a molecule that was first known to confer protection to the fetus from destruction by the immune system of its mother, thus critically contributing to fetal-maternal tolerance. The first functional finding constituted the basis for HLA-G research and can be summarized as such: HLA-G, membrane-bound or soluble, strongly binds its inhibitory receptors on immune cells (NK, T, B, monocytes/dendritic cells), inhibits the functions of these effectors, and so induces immune inhibition.

Poids moléculaire: 50.5 kDa. Due to glycosylation, the protein migrates to 58-63 kDa based on Tris-Bis PAGE result.

UniProt: O02948

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints, Human Leukocyte Antigen (HLA) in Adaptive Immune Response