IDH1 Protein (AA 2-414) (His tag)

N° du produit ABIN7274843

Protéine Recombinant IDH1 exprimée dans Escherichia coli (E. coli).

Aperçu rapide pour IDH1 Protein (AA 2-414) (His tag) (ABIN7274843)

Antigène: IDH1 (Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Pureté: > 95 % as determined by Tris-Bis PAGE,> 90 % as determined by HPLC

Détail du produit

Attributs du protein: AA 2-414

Purification/Conjugué: Cette IDH1 protéine est marqué à la His tag.

Fonction: Human IDH1 Protein

Séquence: Ser2-Leu414

Attributs du produit: Recombinant Human IDH1 Protein is expressed from E.coli with His tag at the C-Terminus.It contains Ser2-Leu414.

Stérilité: 0.22 μm filtered

niveau d'endotoxine: Less than 1EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Supplied as 0.22μm filtered solution in 50 mM Tris, 200 mM NaCl, 1 mM DTT, 10 % Glycerol ( pH 7.5).

Agent conservateur: Dithiothreitol (DTT)

Précaution d'utilisation: This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -80 °C

Stockage commentaire: Valid for 12 months from date of receipt when stored at -80°C.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Date de péremption: 12 months

Détail du antigène

Antigène: IDH1 (Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1))

Autre désignation: IDH1

Sujet: Isocitrate dehydrogenase (IDH) is a metabolic enzyme that converts isocitrate to α-ketoglutarate (α-KG). Genetic gain-of-function mutations in IDH1 and IDH2 confer a neomorphic activity that allow reduction of α -KG to (R)-2- hydroxyglutarate, the accumulation of which results in the development of cancers like low grade gliomas and leukemia.Isocitrate dehydrogenase 1 (IDH1) is the most frequently mutated metabolic gene in cancer.

Poids moléculaire: 47.35 kDa same as Tris-Bis PAGE result.

UniProt: O75874

Pathways: L'effet Warburg