CD34 Protein (CD34) (Biotin,His-Avi Tag)
Aperçu rapide pour CD34 Protein (CD34) (Biotin,His-Avi Tag) (ABIN7489026)
Antigène
Voir toutes CD34 ProtéinesType de proteíne
Origine
Source
Pureté
Classe de qualité
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Purification/Conjugué
- Cette CD34 protéine est marqué à la Biotin,His-Avi Tag.
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Fonction
- Biotinylated Human CD34 Protein, His,Avitag™ (MALS verified)
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Séquence
- Ser 32 - Thr 290
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Attributs du produit
- Biotinylated Human CD34 Protein, His,Avitag is expressed from human 293 cells (HEK293). It contains AA Ser 32 - Thr 290 (Accession # P28906-1).
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niveau d'endotoxine
- 1.0 EU per μg
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Commentaires
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This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™). (Biotin,10xHis , Avi) The protein has a calculated MW of 31.1 kDa. The protein migrates as 50-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- PBS, pH 7.4
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Stock
- -20 °C
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Stockage commentaire
- -20°C
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- CD34
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Autre désignation
- CD34
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Sujet
- CD34 Molecule is a cluster of differentiation molecule present on certain cells within the human body. It is a cell surface glycoprotein and functions as a cell-cell adhesion factor. It may also mediate the attachment of stem cells to bone marrow extracellular matrix or directly to stromal cells. As a ~ 110 kDa monomeric cell surface antigen, CD34 is highly glycosylated with nine potential N-linked and numerous potential O-linked glycosylation sites in its extracellular domain. The CD34 protein is a member of a family of single-pass transmembrane sialomucin proteins that show expression on early hematopoietic and vascular-associated tissue. CD34 is also an important adhesion molecule and is required for T cells to enter lymph nodes. It is expressed on lymph node endothelia whereas the L-selectin to which it binds is on the T cell. It was indicated that CD34 is a phosphorylation target for activated PKC, and couples to the hematopoietic adapter protein CrkL, which were involved in CD34 signaling pathways. CD34 is abberantly expressed in many kinds of tumors and is implicated in leukemogenesis.
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Poids moléculaire
- 31.1 kDa
Antigène
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