Claudin 9 Protein-VLP (CLDN9)

N° du produit ABIN7488753

Protéine VLP Claudin 9 exprimée dans HEK-293 Cells.

Aperçu rapide pour Claudin 9 Protein-VLP (CLDN9) (ABIN7488753)

Antigène: Claudin 9 (CLDN9)

Type de proteíne: VLP

Origine: Humain

Source: HEK-293 Cells

Détail du produit

Fonction: Human Claudin-9 / CLDN9 Full Length Protein (VLP)

Séquence: Met 1 -Val 217

Attributs du produit: Human Claudin-9 Full Length Protein-VLP is expressed from human 293 cells (HEK293). It contains AA Met 1 -Val 217 (Accession # O95484-1).

niveau d'endotoxine: 1.0 EU per μg

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS, Arginine, pH 7.4

Stock: -80 °C

Stockage commentaire: -70°C

Détail du antigène

Antigène: Claudin 9 (CLDN9)

Autre désignation: Claudin-9

Sujet: Claudin-9 belongs to the claudin family. Claudins constitute integral membrane proteins responsible for solute and electrolyte permeability of the tight junction that serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Tight junctions also play a critical role in maintaining cell polarity and signal transductions. Claudin-9 creates charge specific channels in the paracellular space, plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity, is required to preserve sensory cells in the hearing organ because claudin-9-defective tight junctions fail to shield the basolateral side of hair cells from the K+-rich endolymph. Its ion barrier function is essential in the cochlea, but appears to be dispensable in other organs. Is one of the entry cofactors for hepatitis C virus, it enables HCV entry into target cells just as efficiently as CLDN1.

Pathways: Cell-Cell Junction Organization, Hepatitis C