Claudin 9 Protein (CLDN9) (His tag,Twin-Strep tag)

N° du produit ABIN7273438

Détail du produit

Antigène: Claudin 9 (CLDN9)

Type de proteíne: Recombinant

Origine: Humain

Source: Cellules d'insectes

Purification/Conjugué: Cette Claudin 9 protéine est marqué à la His tag,Twin-Strep tag.

Fonction: Human Claudin-9 / CLDN9 Protein, His,Twin-Strep Tag (active membrane protein, SPR verified)

Séquence: Ala 2 - Val 217

Attributs du produit: Human Claudin-9, His,Twin-Strep Tag (CL9-H5586) is expressed from Baculovirus-Insect cells. It contains AA Ala 2 - Val 217 (Accession # O95484-1).

Pureté: >90 % as determined by SDS-PAGE.

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Classe de qualité: SPR verified

Information d'application

Indications d'application: This protein carries a polyhistidine tag and a twin strep tag. The protein has a calculated MW of 27.9 kDa. The protein migrates as 23-24 kDa under reducing (R) condition due to glycosylation.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 50 mM HEPES, 150 mM NaCl, DDM, CHS, pH 7.5

Stock: -80 °C

Stockage commentaire: -70°C

Détail du antigène

Antigène: Claudin 9 (CLDN9)

Autre désignation: Claudin-9 / CLDN9  (CLDN9 Produits)

Synonymes: CLDN9 Protein, nmf329 Protein, claudin 9 Protein, CLDN9 Protein, Cldn9 Protein

Sujet: Synonyms:CLDN9,Description:Claudin-9 belongs to the claudin family. Claudins constitute integral membrane proteins responsible for solute and electrolyte permeability of the tight junction that serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Tight junctions also play a critical role in maintaining cell polarity and signal transductions. Claudin-9 creates charge specific channels in the paracellular space, plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity, is required to preserve sensory cells in the hearing organ because claudin-9-defective tight junctions fail to shield the basolateral side of hair cells from the K+-rich endolymph. Its ion barrier function is essential in the cochlea, but appears to be dispensable in other organs. Is one of the entry cofactors for hepatitis C virus, it enables HCV entry into target cells just as efficiently as CLDN1.

Poids moléculaire: 27.9 kDa

Pathways: Cell-Cell Junction Organization, Hepatitis C