HRG Protein (His tag)

N° du produit ABIN7536456

Détail du produit

Antigène: HRG (Histidine-Rich Glycoprotein (HRG))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette HRG protéine est marqué à la His tag.

Fonction: Recombinant Human HRG/HPRG Protein

Séquence: VSPTDCSAVE PEAEKALDLI NKRRRDGYLF QLLRIADAHL DRVENTTVYY LVLDVQESDC SVLSRKYWND CEPPDSRRPS EIVIGQCKVI ATRHSHESQD LRVIDFNCTT SSVSSALANT KDSPVLIDFF EDTERYRKQA NKALEKYKEE NDDFASFRVD RIERVARVRG GEGTGYFVDF SVRNCPRHHF PRHPNVFGFC RADLFYDVEA LDLESPKNLV INCEVFDPQE HENINGVPPH LGHPFHWGGH ERSSTTKPPF KPHGSRDHHH PHKPHEHGPP PPPDERDHSH GPPLPQGPPP LLPMSCSSCQ HATFGTNGAQ RHSHNNNSSD LHPHKHHSHE QHPHGHHPHA HHPHEHDTHR QHPHGHHPHG HHPHGHHPHG HHPHGHHPHC HDFQDYGPCD PPPHNQGHCC HGHGPPPGHL RRRGPGKGPR PFHCRQIGSV YRLPPLRKGE VLPLPEANFP SFPLPHHKHP LKPDNQPFPQ SVSESCPGKF KSGFPQVSMF FTHTFPK

Specificité: Val19-Lys525

Pureté: > 95 % by SDS-PAGE.

Stérilité: 0.22 μm filtered

niveau d'endotoxine: <0.001 EU/μg

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Concentration: 0.82 mg/mL

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Stock: -20 °C,-80 °C

Stockage commentaire: Store the lyophilized protein at -20°C to -80°C for 12 months.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.

Détail du antigène

Antigène: HRG (Histidine-Rich Glycoprotein (HRG))

Autre désignation: HRG/HPRG (HRG Produits)

Synonymes: AI265597 Protein, AW413091 Protein, D16jh2 Protein, D18020 Protein, Hprg Protein, Hrgp Protein, HPRG Protein, HRGP Protein, THPH11 Protein, HRG1 Protein, histidine rich glycoprotein Protein, histidine-rich glycoprotein Protein, HRG Protein, LOAG_12427 Protein, LOC100597044 Protein, Hrg Protein

Sujet:

Description: Histidine-rich glycoprotein, also known as HRG and HPRG, is a glycoprotein located in plasma and platelets and contains an unusually large amount of histidine and proline.The specific functions of HRG remain unclear, but it is known that the protein binds heme, dyes, and divalent metal ions. It inhibits rosette formation and interacts with heparin, thrombospondin, and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis, and the reduction of inhibition of coagulation indicate a potential prothrombotic effect. HPRG is evolutionarily, functionally, and structurally related to cleaved high molecular weight kininogen (HKa), an anti-angiogenic polypeptide that stimulates apoptosis of proliferating endothelial cells through binding to cell-surface tropomyosin. The antiangiogenic activity of the multidomain plasma protein HPRG is localized to its histidine-proline-rich (H/P) domain and has recently been shown to be mediated, at least partially, through binding to cell-surface tropomyosin in fibroblast growth factor-2-activated endothelial cells.

Name: HPRG, HRGP, THPH11,HRG

ID gène: 3273

UniProt: P04196