Calnexin Protein (CANX) (His tag)

N° du produit ABIN7668285

Protéine Recombinant Calnexin exprimée dans Escherichia coli (E. coli).

Aperçu rapide pour Calnexin Protein (CANX) (His tag) (ABIN7668285)

Antigène: Calnexin (CANX)

Type de proteíne: Recombinant

Activité biologique: Inactive

Origine: Humain

Source: Escherichia coli (E. coli)

Pureté: > 95 %

Détail du produit

Purification/Conjugué: Cette Calnexin protéine est marqué à la His tag.

Fonction: Recombinant CANX/Calnexin protein (His tag)

Séquence: His 21-Lys 300

Purification: > 95 % as determined by reducing SDS-PAGE.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: < 10 EU/mg of the protein as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % -8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: Calnexin (CANX)

Autre désignation: CANX,Calnexin

Sujet: Calnexin/CANX is a single-pass type I membrane protein which belongs to the calreticulin family. It consists of a large N-terminal calcium-binding lumenal domain, a single transmembrane helix and a short (90 residues), acidic cytoplasmic tail. The function of calnexin is to retain unfolded or unassembled N-linked glycoproteins in the endoplasmic reticulum. Calnexin is a calcium-binding protein that interacts briefly with newly synthesized glycoproteins in the endoplasmic reticulum. Calnexin may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. Calnexin seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Calnexin dwindles with aging and might contribute to a cytoprotection in an array of human age-related diseases.,CANX,Calnexin,IP90,Major Histocompatibility Complex Class I Antigen-Binding Protein p88,p90

Poids moléculaire:

calculated_mw: 30.7 kDa

observed_mw: 42 kDa

UniProt: P27824

Pathways: Signalisation MAPK, Thyroid Hormone Synthesis