Pleiotrophin Protein (PTN) (His tag)

N° du produit ABIN7669446

Protéine Recombinant Pleiotrophin exprimée dans Escherichia coli (E. coli).

Aperçu rapide pour Pleiotrophin Protein (PTN) (His tag) (ABIN7669446)

Antigène: Pleiotrophin (PTN)

Type de proteíne: Recombinant

Activité biologique: Inactive

Origine: Humain

Source: Escherichia coli (E. coli)

Pureté: > 98 %

Détail du produit

Purification/Conjugué: Cette Pleiotrophin protéine est marqué à la His tag.

Fonction: Recombinant Human Pleiotrophin protein(N-His)

Séquence: Gly 33-Asp 168

Stérilité: 0.2 μm filtered

niveau d'endotoxine: < 0.01 EU per μg of the protein as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: Pleiotrophin (PTN)

Autre désignation: Pleiotrophin

Sujet: HB-GAM belongs to the pleiotrophin family. During embryonic and early postnatal development, HB-GAM is expressed in the central and peripheral nervous system and also in several non-neural tissues, notably lung, kidney, gut and bone. While in the adult central nervous system, it is expressed in an activity-dependent manner in the hippocampus where it can suppress long term potentiation induction. HB-GAM has a low expression in other areas of the adult brain, but it can be induced by ischemic insults, or targeted neuronal damaged in the entorhinal cortex or in the substantia nigra pars compacta. It is structurally related to midkine and retinoic acid induced heparin-binding protein and has a high affinity for heparin. HB-GAM binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation. It also functions as a secreted growth factor and induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells.,Heparin Affin Regulatory Protein (HARP),Heparin-Binding Growth Factor-8 (HBGF-8),Osteoblast-Specif ic Factor 1 (OSF-1),PTN

Poids moléculaire:

calculated_mw: 19.9 kDa

observed_mw: 18 kDa

UniProt: P21246

Pathways: Signalisation RTK