Sclerostin Protein (SOST) (AA 24-213) (His tag)

N° du produit ABIN7669713

Protéine Recombinant Sclerostin exprimée dans Escherichia coli (E. coli).

Aperçu rapide pour Sclerostin Protein (SOST) (AA 24-213) (His tag) (ABIN7669713)

Antigène: Sclerostin (SOST)

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Application: Immunogen (Imm)

Pureté: > 95 % as determined by reducing SDS-PAGE.

Détail du produit

Attributs du protein: AA 24-213

Purification/Conjugué: Cette Sclerostin protéine est marqué à la His tag.

Fonction: Recombinant Human SOST Protein (His Tag)

Séquence: Gln24-Tyr213

Stérilité: 0.2 μm filtered

niveau d'endotoxine: < 10 EU/mg of the protein as determined by the LAL method

Biological Activity Comment: Not validated for activity

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with 5 % Trehalose and 5 % Mannitol.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: Sclerostin (SOST)

Autre désignation: SOST

Sujet: CDD,DAND6,SOST1,VBCH,Sclerostin, also known as SOST, is a member of the Cerberus/DAN family of BMP antagonists. SOST is asecreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain. It shows sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. SOST is produced by the osteocyte and has anti-anabolic effects on bone formation. It is a negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.

Poids moléculaire:

Calculated MW: 20.8 kDa

Observed MW: 28 kDa

ID gène: 50964

UniProt: Q9BQB4