CNTF Protéine
Aperçu rapide pour CNTF Protéine (ABIN7849711)
Antigène
Voir toutes CNTF ProtéinesType de proteíne
Origine
Source
Application
Pureté
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Fonction
- Recombinant Human CNTF Protein
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Stérilité
- 0.2 μm filtered
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niveau d'endotoxine
- <1 EU/μg by LAL test
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Indications d'application
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Dissolve the lyophilized protein in distilled water(It is not recommended to reconstitute to a concentration<100 μg/mL.)
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Buffer
- Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 6 % Sucrose, 4 % Mannitol, 0.05 % Tween 80, pH 8.0.
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Stock
- 4 °C,-20 °C,-80 °C
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Stockage commentaire
- Ship at 4°C.Upon receipt, aliquot and store at -20°C or -80°C for long term. Avoid repeated freeze and thaw cycles.
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- CNTF (Ciliary Neurotrophic Factor (CNTF))
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Autre désignation
- CNTF
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Sujet
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Synonyms: CNTF, Hciliary neurotrophic factor
Description: Recombinant human CNTF is produced by the E.coli system, with the target gene encoding Ala2-Met200 expressed.
Background: Ciliary neurotrophic factor is a protein that in humans is encoded by the CNTF gene. The protein encoded by this gene is a polypeptide hormone and neurotrophic factor whose actions have mainly been studied in the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neural populations including astrocytes. It is a hypothalamic neuropeptide that is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. In addition to the predominant monocistronic transcript originating from this locus, the gene is also cotranscribed with the upstream ZFP91 gene.
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UniProt
- P26441
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Pathways
- Signalistation JAK/STAT
Antigène
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