YWHAB Protéine

N° du produit ABIN7938556

Protéine Recombinant YWHAB exprimée dans Escherichia coli (E. coli).

Aperçu rapide pour YWHAB Protéine (ABIN7938556)

Antigène: YWHAB (14-3-3 alpha + beta (YWHAB))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Application: Activity Assay (AcA), Functional Studies (Func), Screening Assay (ScA)

Détail du produit

Fonction: Recombinant YWHAB protein

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Recombinant YWHAB protein is supplied in 25 mM Tris pH 8.0, 300 mM NaCl, 20 % glycerol, 0.5 mM TCEP.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Stock: -80 °C

Stockage commentaire: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Détail du antigène

Antigène: YWHAB (14-3-3 alpha + beta (YWHAB))

Autre désignation: YWHAB

Sujet:

Protein Background: YWHAB (14-3-3 protein beta/alpha) is a member of the highly conserved 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13.

Short Description: Recombinant YWHAB protein that includes full length of human YWHAB protein (accession number NP_003395.1) was expressed in E. coli and contains an N-terminal His tag with a molecular weight of 30.25 kDa. The purity of the protein is ≥ 95 % by SDS-PAGE.

Aliases: KCIP-1, 14-3-3 protein beta/alpha, protein 1054, GW128

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Myometrial Relaxation and Contraction, Maintenance of Protein Location