EPH Receptor A2 Protein (EPHA2) (AA 561-976)

N° du produit ABIN7938796

Cette protéine Recombinant EPH Receptor A2 est exprimée dans Baculovirus infected Insect Cells.

Aperçu rapide pour EPH Receptor A2 Protein (EPHA2) (AA 561-976) (ABIN7938796)

Antigène: EPH Receptor A2 (EPHA2)

Type de proteíne: Recombinant

Origine: Humain

Source: Baculovirus infected Insect Cells

Application: Activity Assay (AcA), Screening Assay (ScA), Functional Studies (Func)

Détail du produit

Attributs du protein: AA 561-976

Fonction: Recombinant EPHA2 (561-976) protein

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Recombinant EPHA2 (561-976) protein is supplied in 25 mM HEPESNaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100 and 0.5 mM TCEP.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Stock: -80 °C

Stockage commentaire: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Détail du antigène

Antigène: EPH Receptor A2 (EPHA2)

Autre désignation: EPHA2

Sujet:

Protein Background: EPHA2(Ephrin type-A receptor 2) is a receptor tyrosine kinase which binds promiscuously membranebound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/ EFNA1 regulates migration, integrin-mediated adhesion, proliferation, and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins.

Short Description: Recombinant EPHA2 (561-976) protein that includes amino acids 561-976 of human EPHA2 protein (accession number NP_004422.2) was expressed in a baculovirus expression system, and contains an N-terminal FLAG tag. The molecular weight of the protein is 48.50 kDa.

Aliases: Ephrin type-A receptor 2, EPH receptor A2, ECK, CTRCT6, EphA2, ARCC2, CTPP1, CTPA

Pathways: Signalisation RTK