PHKG2 Protéine

N° du produit ABIN7939420

Cette protéine Recombinant PHKG2 est exprimée dans Baculovirus infected Insect Cells.

Aperçu rapide pour PHKG2 Protéine (ABIN7939420)

Antigène: PHKG2 (phosphorylase Kinase, gamma 2 (Testis) (PHKG2))

Type de proteíne: Recombinant

Origine: Humain

Source: Baculovirus infected Insect Cells

Application: Functional Studies (Func), Activity Assay (AcA), Screening Assay (ScA)

Détail du produit

Fonction: Recombinant PHKG2 protein

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Recombinant PHKG2 protein is supplied in 25 mM HEPES-NaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Stock: -80 °C

Stockage commentaire: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Détail du antigène

Antigène: PHKG2 (phosphorylase Kinase, gamma 2 (Testis) (PHKG2))

Autre désignation: PHKG2

Sujet:

Protein Background: Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, and the hepatic isoform is encoded by this gene. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9C, also known asautosomal liver glycogenosis. PHKG2 (Phosphorylase Kinase Catalytic Subunit Gamma 2) mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. May regulate glycogeneolysis in the testis. Diseases associated with PHKG2 include Glycogen Storage Disease Ixc and Glycogen Storage Disease Due To Liver Phosphorylase Kinase Deficiency.

Short Description: Recombinant PHKG2 protein was expressed in baculovirus expression system as the full length protein (accession number NP_000285.1) with a N-terminal FLAG tag. The molecular weight of the protein is 47.7 kDa.

Aliases: Phosphorylase Kinase Catalytic Subunit Gamma 2

Pathways: Cellular Glucan Metabolic Process, Regulation of Carbohydrate Metabolic Process