SMAD2 Protéine

N° du produit ABIN7939588

Cette protéine Recombinant SMAD2 est exprimée dans Baculovirus infected Insect Cells.

Aperçu rapide pour SMAD2 Protéine (ABIN7939588)

Antigène: SMAD2 (SMAD, Mothers Against DPP Homolog 2 (SMAD2))

Type de proteíne: Recombinant

Origine: Humain

Source: Baculovirus infected Insect Cells

Application: Activity Assay (AcA), Functional Studies (Func), Screening Assay (ScA)

Détail du produit

Fonction: Recombinant SMAD2 protein

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Recombinant SMAD2 protein is supplied in 25 mM HEPES pH 7.5, 300 mM NaCl, 20 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Stock: -80 °C

Stockage commentaire: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Détail du antigène

Antigène: SMAD2 (SMAD, Mothers Against DPP Homolog 2 (SMAD2))

Autre désignation: SMAD2

Sujet:

Protein Background: The transforming growth factor-beta (TGF-b) superfamily signaling controls a wide variety of biological processes from development to pathogenesis primarily through intracellular Smad proteins. Smads are structurally and functionally grouped into three subfamilies: five receptor-activated Smads (R-Smads), one common Smad and two inhibitory Smads. Of R-Smads, Smad2 and Smad3 (Smad2/3 thereafter for simplicity) transduce activin and TGF-b signals, whereas Smad1, Smad5 and Smad8 transduce signals from the BMP/GDF (Bone Morphogenetic Proteins/ Growth Differentiation Factor) family. SMAD2 is key intracellular signal transducers for TGF-b signaling and their transcriptional activities are controlled through reversible phosphorylation and nucleocytoplasmic shuttling.

Short Description: Recombinant SMAD2 protein was expressed in a baculovirus expression system as the full length protein (accession number NP_005892.1) with an N-terminal FLAG tag. The molecular weight of SMAD1 is 53.58 kDa.

Aliases: SMAD family member 2, MADR2, MADH2, Mothers Against Decapentaplegic Homolog 2, HMAD-2

Pathways: Cycle Cellulaire, Hormone Transport, Chromatin Binding, Protein targeting to Nucleus