UBE2C Protéine

N° du produit ABIN7939679

Protéine Recombinant UBE2C exprimée dans Escherichia coli (E. coli).

Aperçu rapide pour UBE2C Protéine (ABIN7939679)

Antigène: UBE2C (Ubiquitin-Conjugating Enzyme E2C (UBE2C))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Application: Activity Assay (AcA), Functional Studies (Func), Screening Assay (ScA)

Détail du produit

Fonction: Recombinant UBE2C protein

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Recombinant UBE2C protein is supplied in 25 mM Tris 8.0, 300 mM NaCl, 20 % glycerol, 0.5 mM TCEP.

Détail du antigène

Antigène: UBE2C (Ubiquitin-Conjugating Enzyme E2C (UBE2C))

Autre désignation: UBE2C

Sujet:

Protein Background: UBE2C (Ubiquitin-conjugating enzyme E2 C) also known as dJ447F3.2 and UBCH10. UBE2C is a member of the E2 ubiquitin-conjugating enzyme family which is required for post-replicative DNA damage repair and plays an important role in various cellular processes. UBE2C can accept ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.

Short Description: Recombinant UBE2C protein that includes full length of human UBE2C protein (accession number NP_008950.1) was expressed in E. coli and contains an N-terminal His tag with a molecular weight of 21.82 kDa. The purity of the protein is ≥ 90 % by SDS-PAGE.

Aliases: Ubiquitin conjugating enzyme E2 C, dj447F3.2, UBCH10

Pathways: Ubiquitin Proteasome Pathway