XRCC1 Protéine

N° du produit ABIN7939755

Cette protéine Recombinant XRCC1 est produite dans Baculovirus infected Insect Cells.

Aperçu rapide pour XRCC1 Protéine (ABIN7939755)

Antigène: XRCC1 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 1 (XRCC1))

Type de proteíne: Recombinant

Origine: Humain

Source: Baculovirus infected Insect Cells

Application: Activity Assay (AcA), Functional Studies (Func), Screening Assay (ScA)

Détail du produit

Fonction: Recombinant XRCC1 protein

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: Recombinant XRCC1 protein is supplied at in 25 mM HEPES pH 7.5, 300 mM NaCl, 20 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Stock: -80 °C

Stockage commentaire: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Détail du antigène

Antigène: XRCC1 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 1 (XRCC1))

Autre désignation: XRCC1

Sujet:

Protein Background: XRCC1 (DNA repair protein XRCC1) also known as RCC and SCAR26. XRCC1 is a scaffold protein that is recruited to SSBs by PARP1 and/or PARP2 activity through direct interaction betweenpoly (ADP-ribose) and the central BRCT domain in XRCC1. XRCC1 in turn interacts with and recruits the enzymes required for SSB repair, including DNA polymerase b, DNA ligase III, polynucleotide kinase/phosphatase and aprataxin. Hereditarymutations in XRCC1 and some of these protein partners result inneurodevelopmental disorders and/or progressive neurodegeneration.

Short Description: Recombinant XRCC1 protein that includes full length of human XRCC1 protein (accession number NP_006288.2) was expressed in Sf9 cells and contains an C-terminal His-FLAG tag with a molecular weight of 72.01 kDa. The purity of the protein is ≥ 80 % by SDS-PAGE.

Aliases: RCC, SCAR26

Pathways: Réparation de l'ADN