CLDN18.2 (AA 28-76) protein (His tag)

N° du produit ABIN8056939

Cette protéine Recombinant CLDN18.2 est exprimée dans Escherichia coli (E. coli).

Aperçu rapide pour CLDN18.2 (AA 28-76) protein (His tag) (ABIN8056939)

Antigène: CLDN18.2

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Pureté: > 95 % as determined by reducing SDS-PAGE.

Détail du produit

Attributs du protein: AA 28-76

Purification/Conjugué: His tag

Fonction: Recombinant Human CLDN18.2/Claudin-18 A2 Protein (His Tag)

Séquence: Asp28-Leu76

Stérilité: 0.2 μm filtered

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 25 mM Tris-HCl, 25 mM NaCl, 0.1 % Triton X-100, 10 % glycerol, 0.1 mM GSH, 0.01 mM GSSG, pH 8.0.

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Date de péremption: 6 months

Détail du antigène

Antigène: CLDN18.2

Sujet: CLDN18,Claudin-18,Claudin-18(CLDN18) is a protein that in humans is encoded by the CLDN18 gene. It belongs to the group of claudins. CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells. CLDN18 plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. CLDN18 has two isoform A1 and isoform A2. IMAB362 (Claudiximab) is a monoclonal antibody against isoform 2 of Claudin-18. It is under investigation for the treatment of gastrointestinal adenocarcinomas and pancreatic tumors. IMAB362 was developed by Ganymed Pharmaceuticals AG.

Poids moléculaire:

Calculated MW: 19.7 kDa

Observed MW: 18 kDa

ID gène: 51208

UniProt: P56856