14-3-3 sigma/SFN Protein (AA 1-248)

N° du produit ABIN935074

Protéine Recombinant 14-3-3 sigma/SFN exprimée dans Escherichia coli (E. coli).

Aperçu rapide pour 14-3-3 sigma/SFN Protein (AA 1-248) (ABIN935074)

Antigène: 14-3-3 sigma/SFN (SFN) (Stratifin (SFN))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Application: SDS-PAGE (SDS)

Pureté: > 95 % pure

Détail du produit

Attributs du protein: AA 1-248

Séquence: MERASLIQKA KLAEQAERYE DMAAFMKGAV EKGEELSCEE RNLLSVAYKN VVGGQRAAWR VLSSIEQKSN EEGSEEKGPE VREYREKVET ELQGVCDTVL GLLDSHLIKE AGDAESRVFY LKMKGDYYRY LAEVATGDDK KRIIDSARSA YQEAMDISKK EMPPTNPIRL GLALNFSVFH YEIANSPEEA ISLAKTTFDE AMADLHTLSE DSYKDSTLIM QLLRDNLTLW TADNAGEEGG EAPQEPQS

Attributs du produit: Purified recombinant Human 14.3.3 sigma protein
Expression System: E.coli

Information d'application

Indications d'application: 14.3.3 Sigma protein has been used in SDS PAGE and may be suitable for use in other assays to be determined by the end user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Supplied as a liquid in 20 mM Tris-HCl buffer, pH 8.0, containing 50 mM NaCl and 10 % glycerol.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.

Stock: RT/-20 °C

Stockage commentaire: Store at 4 °C for short term storage (1/2 weeks). Aliquot and store at -20 °C or - 70 °C for long term storage.

Détail du antigène

Antigène: 14-3-3 sigma/SFN (SFN) (Stratifin (SFN))

Autre désignation: 14.3.3 sigma

Sujet: 14-3-3 sigma, also known as Stratifin (SFN), belongs to the 14-3-3 family. The 14-3-3 family of proteins plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways. 14-3-3 proteins are highly conserved and ubiquitously expressed. There are at least seven isoforms, beta, gamma, epsilon, sigma, zeta, tau and eta that have been identified in mammals. 14-3-3 sigma was identified as an epithelial cell marker and appeared to function as a tumor suppressor whose expression can be down regulated via methylation. Loss of 14-3-3 sigma expression results in a defective G2/M phase checkpoint and appears to contribute to both epithelial and non-epithelial tumorigenesis. Recombinant human 14-3-3 sigma was expressed in E. coli and purified by using conventional chromatography techniques.
Alternative Names: HME1 protein, SFN protein, 14.3.3 sigma, Epithelial cell marker protein 1 protein, stratifin protein, 14-3-3 sigma protein, 14/3/3 sigma protein, YWHAS protein, 14-3-3 sigma, 14/3/3 sigma, 14-3-3 sigma

Poids moléculaire: 27.7 kDa (248 AA)

Pathways: Signalisation p53, Myometrial Relaxation and Contraction