Klotho Protein (KL)
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- Antigène Voir toutes Klotho (KL) Protéines
- Klotho (KL)
- Type de proteíne
- Recombinant
- Activité biologique
- Active
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Origine
- Humain
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Source
- CHO Cells
- Séquence
- EPGDGAQTWA RFSRPPAPEA AGLFQGTFPD GFLWAVGSAA YQTEGGWQQH GKGASIWDTF THHPLAPPGD SRNASLPLGA PSPLQPATGD VASDSYNNVF RDTEALRELG VTHYRFSISW ARVLPNGSAG VPNREGLRYY RRLLERLREL GVQPVVTLYH WDLPQRLQDA YGGWANRALA DHFRDYAELC FRHFGGQVKY WITIDNPYVV AWHGYATGRL APGIRGSPRL GYLVAHNLLL AHAKVWHLYN TSFRPTQGGQ VSIALSSHWI NPRRMTDHSI KECQKSLDFV LGWFAKPVFI DGDYPESMKN NLSSILPDFT ESEKKFIKGT ADFFALCFGP TLSFQLLDPH MKFRQLESPN LRQLLSWIDL EFNHPQIFIV ENGWFVSGTT KRDDAKYMYY LKKFIMETLK AIKLDGVDVI GYTAWSLMDG FEWHRGYSIR RGLFYVDFLS QDKMLLPKSS ALFYQKLIEK NGFPPLPENQ PLEGTFPCDF AWGVVDNYIQ VSQLTKPISS LTKPYH
- Attributs du produit
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Purified recombinant Human Klotho protein
Expression System: CHO cells
Bioactivity: Determined by the dose-dependent stimulation of the proliferation of Mouse NIH-3T3 cells. Recombinant human Klotho is effective in a concentration range of 0.5-2.0 µg/mL. - Pureté
- > 98 % pure
- niveau d'endotoxine
- < 0.1 ng per µg (1 EU/µg).
- Top Product
- Discover our top product KL Protéine
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Klotho (KL) (AA 34-981) protein (His tag)
Crystallography grade KL Origine: Humain Hôte: Cellules d'insectes Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Klotho (KL) (AA 35-982) protein (His tag)Crystallography grade KL Origine: Souris Hôte: Cellules d'insectes Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Klotho (KL) (AA 34-1012) protein (rho-1D4 tag)Crystallography grade KL Origine: Humain Hôte: Cellules d'insectes Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Klotho (KL) (AA 35-1014) protein (rho-1D4 tag)Crystallography grade KL Origine: Souris Hôte: Cellules d'insectes Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Klotho (KL) proteinKL Origine: Rat Hôte: Escherichia coli (E. coli) Recombinant > 95 % SDS, WB, ELISA, IP
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- Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Supplied as a lyophilized powder.
- Conseil sur la manipulation
- Avoid repeated freeze/thaw cycles.
- Stock
- RT/-20 °C
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- Antigène
- Klotho (KL)
- Autre désignation
- Klotho (KL Produits)
- Synonymes
- alpha-kl Protein, KL Protein, LOC100223456 Protein, klotho Protein, Klotho Protein, KL Protein, Kl Protein, kl Protein, LOC100533542 Protein
- Sujet
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Klotho is a glycosylated protein that plays an important role in the regulation of phosphate and calcium homeostasis. Human Klotho exists in both membrane bound and secreted forms, and is predominantly expressed in the kidney convoluted tubules, and to a lesser extent, in the brain, reproductive organs, endocrine glands, urinary bladder, skeletal muscle, placenta, and colon,. The full length transmembrane form has a large extracellular domain composed of two homologous subunits termed KL1 and KL2, which contain 516 and 439 amino acid residues, respectively, The predominant circulating form, which is derived from alternative RNA splicing, contains the KL1 subunit and constitutes the N-terminal sequence of transmembrane Klotho. A third Klotho protein of about 128 kDa has been identified in the blood and cerebrospinal fluid.
Alternative Names: aKlotho protein, KLA protein - Pathways
- Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Hormone Activity, Growth Factor Binding
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