IL-31 Protéine

N° du produit ABIN988074

Cette protéine IL-31 est exprimée dans Escherichia coli (E. coli).

Aperçu rapide pour IL-31 Protéine (ABIN988074)

Antigène: IL-31 (IL31) (Interleukin 31 (IL31))

Activité biologique: Active

Origine: Humain

Source: Escherichia coli (E. coli)

Pureté: > 97 % by SDS-PAGE and HPLC analyses.

Détail du produit

Séquence: SHTLPVRLLR PSDDVQKIVE ELQSLSKMLL KDVEEEKGVL VSQNYTLPCL SPDAQPPNNI HSPAIRAYLK TIRQLDNKSV IDEIIEHLDK LIFQDAPETN ISVPTDTHEC KRFILTISQQ FSECMDLALK SLTSGAQQAT

Attributs du produit: Fully biologically active when compared to standard.Measured by its ability to induce STAT3 activation in U-87 MG human glioblastoma/astrocytoma cells. 5 ng/mL of rhIL31 can effectively induce STAT3 activation.

niveau d'endotoxine: Level Less than 1EU/µg of rHuIL-31 as determined by LAL method

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20°C. Further dilutions should be made in appropriate buffered solutions.

Stock: 4 °C

Détail du antigène

Antigène: IL-31 (IL31) (Interleukin 31 (IL31))

Autre désignation: Interleukin-31 (IL-31)

Sujet: Human IL-31 is a T-cell derived cytokine that shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. It signals through a receptor complex comprised of GPL (GP130-like, IL-31RA) and OSMR (Oncostatin M receptor). GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL-31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases. Synonym:. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in PBS,pH 7.4.

Poids moléculaire: Approximately 15.8 kDa, a single non-glycosylated polypeptide chain containing 141 amino acids.